Dosing
For up-to-date information, go to http://hivinsite.ucsf.edu/tables.
CrCl > 80: 1250 mg po q 12 or 750 mg po q 8 h.
CrCl 80-50: 1250 mg po q 12 or 750 mg po q 8 h.
CrCl 50-10: 1250 mg po q 12 or 750 mg po q 8 h.
CrCl < 10: 1250 mg po q 12 or 750 mg po q 8 h.
Hemodialysis:
Peritoneal dialysis:
Important side effects
Diabetes mellitus (new-onset and exacerbation), hyperglycemia, diarrhea, fat redistribution.
Important drug interactions
Alfuzosin, amiodarone, amprenavir, aprepitant, astemizole, atorvastatin, azithromycin, cannabis, carbamazepine, caspofungin, cerivastatin, cisapride, cyclosporine, darifenacin, delavirdine, didanosine, eletriptan, ergot derivatives, erlotinib, eszopiclone, ethinyl estradiol, etonogestrel, felodipine, fentanyl, fosamprenavir, fosphenytoin, indinavir, lovastatin, mestranol, methadone, midazolam, norethindrone, norgestrel, phenobarbital, phenytoin, pimozide, quinidine, rifabutin, rifampin, rifapentine, ritonavir, saquinavir, sildenafil, simvastatin, st john's wort, tacrolimus, tadalafil, terfenadine, triazolam, vardenafil, voriconazole, zidovudine.
Rants and Screeds
Pearls
Treatment of choice
Use for
HIV.
Don't use for
Class
Protease inhibitor.
Last update 11/29/19