Not available in the UK or U.S.
Dosing
CrCl > 80: 500 mg po q 6 x 3d; may need to be repeated in a week.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Long qt and ventricular arrhythmias.
Important drug interactions
Antipsychotics, arsenic trioxide, astemizole, aurothioglucose, bepridil, chloral hydrate, chloroquine, chlorpromazine, cisapride, clarithromycin, class i antiarrhythmic agents, class ia antiarrhythmic agents, class iii antiarrhythmic agents, cotrimoxazole, dolasetron, droperidol, enflurane, erythromycin, erythromycin/sulfisoxazole, fluconazole, fluoxetine, foscarnet, gemifloxacin, halothane, isoflurane, isradipine, itraconazole, levomethadyl, lidoflazine, mefloquin, mesoridazine, octreotide, pentamadine, pimozide, probucol, prochlorperazine, spiramycin, sulfamethoxazole, telithromycin, telithromycin, thioridazine, tricyclic antidepressants, trifluoperazine, trimethoprim, vasopressin, venlafaxine, ziprasidone, zolmitriptan.
Rants and Screeds
Pearls
Do not take with grapefruit.
Treatment of choice
Use for
P. falciparum and P. vivax.Don't use for
Class
Last update 11/27/19