Infectious Disease Compendium

Comparison of Antibacterials

Gram-positive Rods

Penicillins
penicillin
2
1
.
.
3
1
3
2
ampicillin/amoxicillin
3
3
.
.
2
1
2
2
amoxicillin/clavulanate
3
3
.
.
2
1
2
2
ampicillin/sulbactam
3
3
.
.
2
1
2
2
nafcillin/oxacillin /dicloxacillin
1
1
.
.
1
1
1
1
mezlocillin/ piperacillin
2.5
1
.
.
1
1
1
2
ticarcillin/clavulanate
1
1
.
.
1
1
1
2
piperacillin/tazobactam
2.5
1
.
.
2
1
1
1
Cephlosporins
---
---
---
---
---
---
---
---
cefazolin / cephalexin
1
1
.
.
1
1
1
1
2nd genration: eg cefuroxime
1
1
.
.
1
1
1
1
cefotaxime / ceftriaxone
1
1
.
.
1
1
1
2
ceftazadime
1
1
.
.
1
1
1
2
cefepime
1
1
.
.
1
1
1
2
Aminoglycosides
---
---
---
---
---
---
---
---
gentamicin / tobramycin
synergy
synergy
synergy
.
1
1
1
2
amikacin
.
.
.
.
1
1
1
2
Macrolides
---
---
---
---
---
---
---
---
erythromycin
1
.
.
.
1
1
1
2
clarithromycin
1
.
.
.
1
1
1
2
azithromycin
1
.
.
.
1
1
1
2
dirithromycin
1
.
.
.
1
1
1
2
telithromycin
1
.
.
.
1
1
1
2
clindamycin
1
.
3
.
3
1
3
2
Tetracyclines
---
---
---
---
---
---
---
---
tetracycline / doxycycline
1
3
2
3
1
1
2
2
tigecycline
1
.
.
.
.
1
.
.
Carbapenems
---
---
---
---
---
---
---
---
ertapenem
1
.
3
.
3(?)
.
?
.
meropenem
2.5
.
3
.
3(?)
.
?
.
imipenem
2.5
.
3
.
3(?)
.
?
.
Misc.
---
---
---
---
---
---
---
---
metronidazole
1
.
1
1
3
3
?
1
aztreonam
1
1
1
1
1
1
1
1
colistin
.
.
.
.
1
.
1
.
rifampin
.
.
.
.
.
1
.
rifaximin
.
.
.
.
1
.
1
.
trimethoprim/sulfamethoxisole
.
.
.
1
.
1
.
vancomycin
2
.
3
.
1
3
1
.
quinupristin/dalfopristin
2
.
.
.
1
.
.
.
linezolid
2
.
.
.
1
?
.
.
daptomycin
2
.
.
.
1
.
.
.
Quinolones
---
---
---
---
---
---
---
---
levofloxacin
1
2
2
2
1
1
.
.
moxifloxacin /gatifloxacin
1
2
2
2
1
1
.
.
ciprofloxacin
1
2
3
3
1
1
.
.

 

3= great. Use an antibiotic empirically if it is a 3.

2.5 = the best we got, but I sure wish we had better. OK to use empirically as we do not have any other choice.

2= adequate if susceptible, use with caution (ie know what you are doing and local susceptibility patterns) but do not rely on it empirically if you do not have susceptibilities.

1.5 = if it is susceptible its great, but is almost never susceptible.

1= no way dude. You want a dead patient?

R = resistant

"?" = looks good in a test tube

"." = placeholder pending data