Dosing
CrCl > 80: 7.5 mg/kg q 12 hours or 15 mg/kg/day.
CrCl 80-50: 60% to 90% q 12 hours.
CrCl 50-10: 30% to 70% q 12 hours.
CrCl < 10: 20% to 30% q 24 to 48 hours.
Hemodialysis:
Peritoneal dialysis:
Important side effects
Oto and nephrotoxicity.
Important drug interactions
Bumetanide, capreomycin, carboplatin, cephalosporins, cidofovir, cyclosporine, ethacrynic acid, furosemide, live typhoid vaccine, lysine, magnesium, nondepolarizing neuromuscular blockers, penicillins, piretanide, succinylcholine, tacrolimus.
Rants and Screeds
Pearls
Treatment of choice
Use for
Bowel sterilization, Endocarditis, Gonorrhea, gram-negative infections, hepatic encephalopathy, necrotizing enterocolitis, surgical infections, Tuberculosis, UTI.
Don't use for
Class
Aminoglycoside.
Last update 11/28/19