Dosing
CrCl > 80: 500 mg - 2 gm IV q 4-6 h.
CrCl 80-50: 500 mg - 2 gm IV q 4-6 h.
CrCl 50-10: 500 mg - 2 gm IV q 8 h.
CrCl < 10: 500 mg - 2 gm IV q 12 h.
Hemodialysis: 500 mg - 2 gm after HD.
Peritoneal dialysis: 1 - 4 g after PD.
Important side effects
Important drug interactions
Rants and Screeds
Pearls
It causes a rash with acute mono, probably more sensitive and specific than a monospot.
Treatment of choice
Use for
Any Streptococci (all). Actinomyces, Anthrax, bacterial Endocarditis prophylaxis, Borrelia burgdorferi infection (Lyme), bronchiectasis, Bronchitis, Chancroid, Chlamydia infections, COPD exacerbation, Endocarditis, endodontic therapy, prophylaxis, Enteric fever, Neisseria, Haemophilus influenzae, Helicobacter pylori, Leptospira infections, Lyme Disease, Meningitis, Otitis media, periodontal disease, Pharyngitis, Pneumonia, Shigella, Sinusitis acute, Cellulitis, Typhoid fever, UTI, Whipples disease.
Don't use for
Class
Penicillin.