Dosing
CrCl > 80: 100 po qd.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Hemolytic anemia with G-6-PD; so test first.
Hypersensitivity.
Important drug interactions
Amprenavir, cotrimoxazole, probenecid, rifabutin, rifampin, rifapentine, saquinavir, trimethoprim, zidovudine.
Rants and Screeds
Pearls
HLA-B*13:01 is a risk for hypersensitivity. To quote the NEJM (PubMed): HLA-B*13:01 "is present in about 2 to 20% of Chinese persons, 1.5% of Japanese persons, 1 to 12% of Indians, and 2 to 4% of Southeast Asians but is largely absent in Europeans and Africans."
Treatment of choice
Use for
Don't use for
Class
Sulphone. Can you hear me?
Last update: 10/28/19