Infectious Disease Compendium

Tenofovir (Viread®)

There is the old form Tenofovir disoproxil, and the newer form, the latter less toxic but more expensive.

Dosing

CrCl Formula

For up-to-date information, go to http://hivinsite.ucsf.edu/tables.

CrCl > 50: Tenofovir disoproxil 300 mg po qd.

Tenofovir alafenamide 25 mg po qd

CrCl 30-49: 300 mg every 48 hr.

CrCl 10-29 mL/min, 300 mg twice weekly.

CrCl 10-29: 300 mg twice weekly.

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Asthenia, bone mineral density loss, diarrhea, flatulence, nausea, vomiting, fat redistribution, hepatitis B exacerbation, lactic acidosis/severe hepatomegaly with steatosis, renal impairment, renal failure, Fanconi syndrome.

Important drug interactions

Atazanavir, didanosine, ritonavir.

Protease inhibitors increase nephrotoxicity more than NNRTI's (PubMed).

Rants and Screeds

Pearls

Treatment of choice

Use for

HIV.

Don't use for

Class

Nucleotide analog reverse transcriptase inhibitor.

Last update 11/30/19