Dosing
CrCl > 80: 1-2 gm q 6 h.
CrCl 80-50: q 8-12 h.
CrCl 50-10: q 12 - 18 h.
CrCl < 10: q 24 h.
Hemodialysis 1/8 initial dose.
Peritoneal dialysis:
Important side effects
No unusual.
Important drug interactions
No unusual.
Rants and Screeds
Pearls
Safe with anaphylactic reactions to other beta-lactams.
Treatment of choice
Use for
Gram-negative aerobic organisms like E. coli and Pseudomonas.
Nebulized aztreonam is used for the treatment of respiratory symptoms in cystic fibrosis.
Don't use for
All gram-positives. And for ESBL, which hydrolyzes aztreonam.
And anaerobes.
Class
Monobactam
Last Update: 04/17/19.