Dosing
CrCl > 80: 3 g q 4-6 h.
CrCl 80-50: 3 g q 4 - 6 h.
CrCl 50-10: q 6 - 8 h.
CrCl < 10: 2 g q 12 h.
Hemodialysis: 3 g then 2 g q 12 h.
Peritoneal dialysis: 3 g q 12 h.
Important side effects
Anaphylaxis, coagulation abnormalities; bleeding time and platelet aggregation, convulsions, hypersensitivity reactions, hypokalemia, rash, thrombophlebitis.
Important drug interactions
Rants and Screeds
A drug of historical interest.
Pearls
Treatment of choice
Use for
Guess if you want half-assed gram-negative penicillin, I suppose you could use this. Arthritis, Cellulitis, Empyema, Endometritis, eye infections, gynecologic infections, Intraabdominal infections, Neutropenic fever, Osteomyelitis, Pneumonia, Sepsis, Sinusitis, surgical prophylaxis, UTI.
Don't use for
Class
Penicillin.
Last update 11/30/19