Dosing
CrCl > 80: 1200 mg over 3 hours. With a half-life of 400 hours, one dose is all that is needed for cellulitis.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Elevated LFT's. Fewer side effects than vancomycin.
Important drug interactions
Rants and Screeds
It costs. $917.56/400 mg vial x 3 vials = $2,752.69. Really. A fully loaded MacBook pro. There seems to be a new era of price gouging.Pearls
Treatment of choice
Use for
All gram positive including VRE and MRSA. Same spectrum as vancomycin, but much better mic's. Only approved for cellulitis, for which it is no worse than vancomycin, the definition of damning with faint praise I suppose.
Don't use for
Osteomyelitis
Class
Lipoglycopeptide.
Curious Cases
Relevant links to my Medscape blog
Last update 11/30/19