Infectious Disease Compendium

Meropenem and vaborbactam (Vabomer)

Dosing

CrCl Formulatteint

CrCl > 80: 4 grams (meropenem 2 g and vaborbactam 2 g) q 8 hours IV over 3 hour

CrCl 30-49: 2 g q 8.

CrCl 25-29: 2 g q 12 h.

CrCl < 15: 1 g a 12 h

Hemodialysis:

Peritoneal dialysis:

Obesity dosing

Important side effects

Agranulocytosis, neutropenia, (rare), diarrhea, nausea, headache, seizures (usually in patients with CNS disorders), toxic epidermal necrolysis, steven-johnson syndrome, erythema multiforme, angioedema.

Important drug interactions

Rants and Screeds

Pearls

It may be safer than imipenem in patients with a type 1 drug reaction to penicillin (PubMed).

Treatment of choice

Use for

Has in vitro activity against Enterobacteriaceae in the presence of some beta-lactamases and extended-spectrum beta-lactamases of the following types: KPC, SME, TEM, SHV, CTX-M, CMY, and ACT. It is not active against bacteria that produce metallo-beta-lactamases or oxacillinases with carbapenemase activity.

Don't use for

Class

Carbapenem.

Last update 11/29/19