Dosing
CrCl > 80: 0.5 - 1 g q 12 h.
CrCl 80-50: 7.5 mg/kg q 24 h.
CrCl 50-10: 7.5 mg/kg q 24-72 h.
CrCl < 10: 7.5 mg/kg q 72 - 96 h.
Hemodialysis: 500 mg after dialysis.
Peritoneal dialysis:
Important side effects
Oto and nephrotoxicity. Arachnoiditis, encephalopathy, optic nerve dysfunction, peripheral neuritis, eosinophilia, fever, neuromuscular blockade, respiratory paralysis, paresthesias, vestibular and cochlear toxicity.
Important drug interactions
Bumetanide, capreomycin, carboplatin, cidofovir, cyclosporine, ethacrynic acid, furosemide, lysine, magnesium, nondepolarizing neuromuscular blockers, piretanide, succinylcholine, tacrolimus.
Rants and Screeds
Pearls
Treatment of choice
Use for
Tuberculosis. Brucella, Chancroid, Endocarditis, granuloma inguinale, Haemophilus influenzae, Mycobacterium infections, Plague, Pseudomonas mallei infections, Rat Bite Fever, Tularemia, UTI, Whipple's disease.
Don't use for
Class
Aminoglycoside.
Last update 11/30/19