Dosing
CrCl > 80:
150 mg intravenously every 12 hours
600mg BID po
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Prolongation of QT interval.
Important drug interactions
Rants and Screeds
Pearls
Don't use in liver failure.
As of 2019, $200 + a day.
Treatment of choice
Use for
Community-acquired Bacterial Pneumonia, where it is no worse than moxifloxicin (Pubmed).
Gram-positives: Streptococcus pneumoniae, Staphylococcus aureus [including MRSA], Enterococcus faecium [including VRE], coagulase negative staphylococci, beta-hemolytic streptococci, viridans group streptococci. Gram-negatives: Haemophilus influenzae, Neisseria gonorrhoeae, Moraxella catarrhalis. Atypicals: Mycoplasma pneumoniae, Legionella pneumophila, and Chlamydophila pneumoniae, Mycoplasma genitalium.
Don't use for
Class
Pleuromutilin antibiotic. Inhibits bacterial protein synthesis by binding to the peptidyl transferase of the 50S bacterial ribosome, to prevent the binding of transfer RNA for peptide transfer.
Last Update: 10/16/19.