Dosing
CrCl > 29: 300mg iv q 12 h.
450 mg po q 12 h.
CrCl 80-50:
CrCl 15–29 mL/min 200 mg IV q 12h
Hemodialysis:
Peritoneal dialysis:
Important side effects
Usual quinolone issue.
Important drug interactions
As with all quinolones, oral divalent cations will bind the drug and prevent absorption.
Rants and Screeds
C. difficile has good MIC, perhaps why there were no cases in the trials.
Treatment of choice
Use for
Approved for Cellulitis and Pneumonia. Good for MRSA (PubMed) and Streptococci.
Not bad for most anaerobes except Prevotella.
Don't use for
Pseudomonas.
Class
Quinolone.
Curious Cases
Relevant links to my Medscape blog