Infectious Disease Compendium

Panniculitis

Diagnosis

An infection of fat.

Epidemiologic Risks

Can be post-op, by direct inoculation or hematogenously. I have seen a pair of spontaneous cases.

More often non-infectious: lupus erythematosus or scleroderma, lymphoma or histiocytosis, sarcoidosis with cutaneous involvement, Alpha 1-antitrypsin deficiency. Pancreatitis as lipase eats adipose. And acinar cell carcinoma of the pancreas causes necrotizing pannicultis.

Microbiology

Anything

Empiric Therapy

Depends of the risks etc.

Pearls

I see most of the cases after abdominal surgery in the morbidly obese. Abdominal wall fat is remarkably poorly vascularized and many antibiotics have poor penetration into adipose.

Infections of large hanging pannuses are particularly hard to treat as impossible to elevate and the inflammation pools in dependent areas.

The plural is Panniculitides, which sounds like a constellation of some sort.

Curious Cases

Relevant links to my Medscape blog

Cases Don't Come in Threes

Last Update: 05/27/18.