Dosing
CrCl > 80: 500 mg IV q 8 h.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Nausea and taste change.
Important drug interactions
Rants and Screeds
Pearls
Treatment of choice
Use for
Approved for cellulitis (Canada and Europe, not the US) and works for hospital-acquired pneumonia (PubMed).
Staphylococcus aureus especially MRSA It has a high affinity for penicillin-binding protein PBP2a, the major determinant of methicillin resistance in staphylococcal species. Ceftobiprole has an MIC 90 of 0.5 mg/mL for methicillin-susceptible S. aureus and an MIC 90 of 2 mg/mL for MRSA.
Also used for penicillin I and R S. pneumoniae and Enterococcus faecalis.
Not available in the US.
Don't use for
Class
Fifth-generation cephalosporin.
Last Update: 08/22/19.