Dosing
CrCl > 80: 2 mg/kg iv q 8 h.
CrCl 80-50: 2 mg/kg iv q 8-12 h.
CrCl 50-10: 2 mg/kg iv q 12-48 h.
CrCl < 10: 2 mg/kg iv q >48 h.
Hemodialysis:
Peritoneal dialysis:
Important side effects
Diarrhea, nausea, vomiting, nephrotoxicity, neuromuscular blockade, respiratory paralysis (concomitant anesthesia, muscle relaxants), ototoxicity.
Important drug interactions
Bumetanide, capreomycin, carboplatin, cidofovir, cyclosporine, ethacrynic acid, furosemide, lysine, magnesium, nondepolarizing neuromuscular blockers, penicillins, piretanide, succinylcholine, tacrolimus.
Rants and Screeds
Pearls
Treatment of choice
Use for
Gram-negative infections. Appendicitis, Cellulitis, Meningitis, Cystic fibrosis, Endocarditis treatment, Neutropenic fever, Gonorrhea, Intraabdominal infections, Peritonitis, Pneumonia, Sepsis, UTI.
Don't use for
Class
Aminoglycoside.
Last update 11/29/19