Dosing
CrCl > 80: 50 mg iv qd.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Abdominal pain, acute renal failure, anaphylaxis, anemia, diarrhea, fever, headache, hemolysis, hemolytic anemia, hyperbilirubinemia, leukopenia, liver function tests abnormal, nausea, neutropenia, phlebitis, rash, rigor, thrombocytopenic disorder, thrombotic thrombocytopenic purpura, vomiting.
Important drug interactions
Nifedipine, sirolimus.
Treatment of choice
Use for
Aspergillus (salvage therapy, only caspofungin has been approved as of 6/7) and Candida. Pneumocystis (in vitro). Prophylaxis for neutropenic fever (better than fluconazole).
Don't use for
Cryptococcus, Zygomycetes.
Class
Echinocandidin.
Last update 11/29/19