Dosing
CrCl Formulatteint
CrCl > 80: 4 grams (meropenem 2 g and vaborbactam 2 g) q 8 hours IV over 3 hour
CrCl 30-49: 2 g q 8.
CrCl 25-29: 2 g q 12 h.
CrCl < 15: 1 g a 12 h
Hemodialysis:
Peritoneal dialysis:
Important side effects
Agranulocytosis, neutropenia, (rare), diarrhea, nausea, headache, seizures (usually in patients with CNS disorders), toxic epidermal necrolysis, steven-johnson syndrome, erythema multiforme, angioedema.
Important drug interactions
Rants and Screeds
Pearls
It may be safer than imipenem in patients with a type 1 drug reaction to penicillin (PubMed).
Treatment of choice
Use for
Has in vitro activity against Enterobacteriaceae in the presence of some beta-lactamases and extended-spectrum beta-lactamases of the following types: KPC, SME, TEM, SHV, CTX-M, CMY, and ACT. It is not active against bacteria that produce metallo-beta-lactamases or oxacillinases with carbapenemase activity.
Don't use for
Class
Last update 11/29/19