Dosing
CrCl Formulatteint
CrCl > 80: 500 mg - 2 gm iv q 8 h. Give with a 4-hour infusion is probably best in the ill ICU patient.
CrCl 80-50: 500 mg - 1 gm iv 8-12h.
CrCl 50-10: 500 mg - 1 gm iv 0.5-1 g q 12 h.
CrCl < 10: 500 mg - 1 gm iv 0.5 g q 24 h.
Hemodialysis:
Peritoneal dialysis:
Important side effects
Agranulocytosis, neutropenia, (rare), diarrhea, nausea, headache, seizures (usually in patients with CNS disorders), toxic epidermal necrolysis, steven-johnson syndrome, erythema multiforme, angioedema.
Important drug interactions
Rants and Screeds
Pearls
It may be safer than imipenem in patients with a type 1 drug reaction to penicillin (PubMed).
Treatment of choice
Use for
Damn near anything. Cellulitis, Cystic fibrosis, Diverticulosis/itis, Neutropenic fever, Intraabdominal infections, Meningitis, Nocardia infections, Pneumonia - nosocomial, UTI, ventriculitis.
Don't use for
Class
Curious Cases
Relevant links to my Medscape blog
Last update 11/29/19