Infectious Disease Compendium

Cephalothin (Keflin®)

Dosing

CrCl Formula

CrCl > 80: 500 mg - 2 g q 4 - 6 h iv.

CrCl 80-50: 500 mg - 2 g q 4 - 6 h iv.

CrCl 50-10: 1-1.5 g q 6 h iv.

CrCl < 10: 500 mg q 8 h iv.

Hemodialysis: 500 mg - 2 g after dialysis.

Peritoneal dialysis: na.

Important side effects

Important drug interactions

Rants and Screeds

Pearls

Treatment of choice

Use for

Streptococci of all types and methicillin-susceptible S. aureus.

Arthritis, Cellulitis, Pneumonia, Osteomyelitis, surgical prophylaxis, UTI.

Don't use for

Class

First-generation cephalosporin.

Last Update: 08/26/19.