Dosing
CrCl > 29: 300mg iv q 12 h.
450 mg po q 12 h.
CrCl 80-50:
CrCl < 29 15–29 mL/min 200 mg IV, Q12h
Hemodialysis:
Peritoneal dialysis:
Important side effects
Usual quinolone issues. Maybe no QT prolongation issues.
Important drug interactions
As with all quinolones, oral divalent cations will bind the drug and prevent absorption.
Rants and Screeds
Treatment of choice
Use for
Approved for Cellulitis and Pneumonia.
It has better activity against S. aureus, including MRSA, and streptococci than other quinolones, including ciprofloxacin and levofloxacin strains.
E. coli and friends, the Enterobacteriaceae.
Active against anaerobes and atypical respiratory pathogens (Legionella and Mycoplasma).
Don't use for
Enterococcus faecium, extended-spectrum β-lactamase Enterobacteriaceae, ceftazidime-resistant Pseudomonas aeruginosa, and Acinetobacter.
Class
Quinolone.