Dosing
CrCl > 80: 125 - 250 mg po q 12 - 24 h.
CrCl 80-50: 125 - 250 mg po q 12 - 24 h.
CrCl 50-10: ?
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
headache, liver failure, hepatitis, nausea, vomiting, severe neutropenia.
Important drug interactions
Cyclosporine, nortriptyline, rifampin, warfarin.
Rants and Screeds
I think the drug is worse than the disease.
Pearls
Treatment of choice
Use for
Dermatophytosis and superficial mycoses aka athlete's foot, chromoblastomycosis, cutaneous Leishmania, cutaneous Sporothrix, fungal joint infection, jock itch, onychomycosis, otitis externa, paracoccidioidomycosis, pyoderma, Ringworm, seborrheic dermatitis, systemic mycoses, tinea capitis, tinea corporis, tinea cruris, tinea pedis, tinea unguium.
Don't use for
Class
Last update 11/30/19