Infectious Disease Compendium

Omadacycline

Dosing

CrCl Formula

CrCl > 80:

  Loading Dose Maintenance
CAP Day 1: 100-200 mg iv 100 mg iv or 300 mg po qd
Cellulitis 100-200 mg iv 100 mg iv or 300 mg po qd
Cellulitis Oral Day 1 and 2: 450 mg po qd 300 mp po qd

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

None unique. 6 150mg tabs cost $1250, so bankruptcy is a risk.

Important drug interactions

Rants and Screeds

Pearls

Treatment of choice

Use for

Approved for CAP (but a higher mortality (2%) rate than moxifloxacin comparator (1%))(PubMed) and cellulitis (PubMed) (PubMed).

Mostly an anti gram-positive antibiotic.

"It is active against most gram-positive organisms, including MRSA, coagulase-negative Staphylococcus, vancomycin-resistant Enterococcus, Streptococcus pyogenes, and S. pneumoniae, and including those resistant to tetracycline...(PubMed)".

Some ESBL E. coli and K. pneumoniae.

Don't use for

Class

A fancy-schmancy tetracycline.

Last update 11/30/19