Diagnosis
Not an infection (?). Fever and a rash, often raised, that looks like a cellulitis. Biopsy makes the diagnosis. It is an infiltrate of the skin by PMN's.
Other organs can be involved.
Review: (PubMed).
Epidemiologic Risks
Half of patients have an underlying, usually hematologic, malignancy. Some are idiopathic. Occasionally due to drugs.
Microbiology
Not applicable.Empiric Therapy
Steroids AFTER the biopsy.
Pearls
Curiously, it can occur during neutropenia, just where those white cells are coming from, I haven't figured out.
And it can be caused by G-CSF.
Last Update: 02/22/19.