Dosing
CrCl > 60: 15 mg per kilogram daily.
CrCl ≥30 to 60 mL/min: 10 mg/kg IV q 24 hr .
CrCl ≥15 to 30 mL/min: 10 mg/kg IV q 48 hr.
Hemodialysis:
Peritoneal dialysis:
Important side effects
Oto and nephrotoxicity.
Important drug interactions
Rants and Screeds
Pearls
Resistant to most aminoglycoside-modifying enzymes.
Treatment of choice
Use for
CRE E. coli and K. pneumoniae UTI (PubMed) and bloodstream infections (PubMed).
So-so for Pseudomonas aeruginosa and Acinetobacter baumannii, same as any other aminoglycoside.
Don't use for
Proteus mirabilis, Providencia, and Morganella morganii. Or Stenotrophomonas maltophilia.
Class
Aminoglycoside. "Plazomicin is an aminoglycoside that is engineered to evade modification by aminoglycoside- modifying enzymes, and it maintains activity in the presence of most mechanisms that lead to resistance in Enterobacteriaceae, including mutations in sites targeted by fluoroquinolones and the production of aminoglycoside-modifying enzymes, extended-spectrum β-lactamases, and carbapenemases (PubMed)."
Last update 02/16/20