Infectious Disease Compendium

Bedaquiline (Sirturo)

Dosing

CrCl Formula

CrCl > 80: 400 mg a day for two weeks and then 200 mg taken three times a week (with at least 48 hours between doses) for the following 22 weeks.

CrCl 80-50:

CrCl 50-10:

CrCl <10:

Hemodialysis : no data.

Peritoneal dialysis: no data.

Important side effects

Common: gastrointestinal (nausea, vomiting, diarrhea, abdominal pain), arthralgias headaches, and chest pain, QT prolongation, liver dysfunction.

Important drug interactions

Rifampin drops the blood levels by half.

Rants and Screeds

Pearls

When resistance occurs, which it has, it has cross resistance with clofazamine.

Use for

MDR Mycobacterium tuberculosis.

Class

Diarylquinoline. It blocks the proton pump for ATP synthase of mycobacteria.

Last Update: 04/19/19.