Infectious Disease Compendium

Comparison of Antibacterials

Anaerobes and Miscellaneous

Penicillins
penicillin
2
3
.
1
1
1
1
1
1
ampicillin/amoxicillin
2
3
.
1
1
1
1
1
1
amoxicillin/clavulanate
3
3
.
1
1
1
1
1
1
ampicillin/sulbactam
3
3
.
1
1
1
1
1
1
nafcillin/oxacillin /dicloxacillin
1
1
1
1
1
1
1
1
1
mezlocillin/ piperacillin
2
.
.
1
1
1
1
1
1
ticarcillin/clavulanate
3
.
.
1
1
1
1
1
1
piperacillin/tazobactam
3
.
.
1
1
1
1
1
1
Cephlosporins
---
---
---
---
---
---
---
---
---
cefazolin / cephalexin
1
.
1
1
1
1
1
1
1
2nd genration: eg cefuroxime
2(5)
.
1
1
1
1
1
1
1
cefotaxime / ceftriaxone
1
.
3
1
1
1
1
1
1
ceftazadime
1
.
2
1
1
1
1
1
1
cefepime
1
.
2
1
1
1
1
1
1
Aminoglycosides
---
---
---
---
---
---
---
---
---
gentamicin / tobramycin
1
.
2
.
.
.
.
.
.
amikacin
1
.
3
.
.
.
.
.
.
Macrolides
---
---
---
---
---
---
---
---
---
erythromycin
1
.
.
3
3
3
2
2
2
clarithromycin
1
.
.
3
3
3
2
2
3
azithromycin
1
.
.
3
3
3
2
2
3
dirithromycin
1
.
.
.
.
.
.
.
.
telithromycin
.
.
.
.
.
.
.
.
.
clindamycin
2 (6)
3
.
1
1
1
1
1
1
Tetracyclines
---
---
---
---
---
---
---
---
---
tetracycline / doxycycline
2
3
.
2
3
3
3
3
3
tigecycline
.
.
.
.
.
.
.
.
.
Carbapenems
---
---
---
---
---
---
---
---
---
ertapenem
3
3
3
1
1
1
1
1
1
doripenam
2
. . . . . . . .
meropenem
3
3
3
1
1
1
1
1
1
imipenem
3
3
3
1
1
1
1
1
1
Misc.
---
---
---
---
---
---
---
---
---
metronidazole
3
1
1
1
1
1
1
1
1
aztreonam
1
1
.
1
1
1
1
1
1
colistin
1
1
1
1
1
1
1
1
1
rifampin
1
1
.
synergy
.
.
.
.
.
rifaximin
1
1
1
1
1
1
1
1
1
trimethoprim/sulfamethoxisole
1
.
3
2
2
2
2
2
2
vancomycin
1
.
1
1
1
1
1
1
1
quinupristin/dalfopristin
1
.
.
.
.
.
.
.
.
linezolid
1
.
.
.
.
.
.
.
.
daptomycin
1
.
.
.
.
.
.
.
.
Quinolones
---
---
---
---
---
---
---
---
---
levofloxacin
1
.
2
3
3
3
3
3
3
moxifloxacin /gatifloxacin
1
.
2
3
3
3
3
3
3
ciprofloxacin
1
.
2
3
3
3
3
3
3

 

3= great. Use an antibiotic empirically if it is a 3.

2.5 = the best we got, but I sure wish we had better. OK to use empirically as we do not have any other choice.

2= adequate if susceptible, use with caution (ie know what you are doing and local susceptibility patterns) but do not rely on it empirically if you do not have susceptibilities.

1.5 = if it is susceptible its great, but is almost never susceptible.

1= no way dude. You want a dead patient?

R = resistant

"?" = looks good in a test tube

"." = placeholder pending data

Notes

(5) cefoxitin, cefotetan, cefmetazole are no longer are soon to be no longer available in the US, the latter two do not get the dot group of Bacteroides.

(6) 30% resistance of Bacteroides reported.