Infectious Disease Compendium

Bezlotoxumab

Review

Dosing

CrCl Formula

CrCl > 80: 10 mg/kg

Important side effects

Increased risk of heart failure in patients with pre-existing congestive heart failure.

Important drug interactions

Rants and Screeds

Costs a fortune, almost 4 grand a vial. Curiously, those who make the product think it is cost-effective. What a surprise.

Pearls

Treatment of choice

Prevents C. difficile recurrence in patients with 1 or more of the following risks: age > 65 years, history of CDI, immunocompromised, or severe CDI.

Use for

C. difficile recurrence in high-risk patients. The absolute reduction is 12-19%, depending on the study methodology (PubMed).

Class

Monoclonal antibody against anti-toxin B.

Last Update: 08/17/19.