Infectious Disease Compendium

Comparison of Antibacterials

Gram-negative Cocci/Coccobacillus

Penicillins
penicillin
2
3
3
1
1
1
3
2
2
2
2
ampicillin/amoxicillin
2
3
3
2
2
3
3
3
3
3
3
amoxicillin/clavulanate
2
3
3
3
2
3
3
3
3
3(?)
3
ampicillin/sulbactam
2
3
3
3
3
3
3
3(?)
3(?)
3(?)
3(?)
nafcillin/oxacillin /dicloxacillin
1
1
1
1
1
1
1
1
1
1
1
mezlocillin/ piperacillin
2
3
3
3
3
3
3
3
3(?)
3(?)
3
ticarcillin/clavulanate
2
3
3
3
3
3
3
3
3(?)
3(?)
3
piperacillin/tazobactam
2
3
3
3
3
3
3
3
3(?)
3(?)
3
Cephlosporins
---
---
---
---
---
---
---
---
---
---
---
cefazolin / cephalexin
1
2
2
2
1
1
1
1
1
3
1
2nd genration: eg cefuroxime
1
3
3
3
3
1
1
1
1
1
1
cefotaxime / ceftriaxone
3
3
3
3
3
3
3
3(?)
3(?)
3(?)
3
ceftazadime
3
3
3
3
3
3
3
3(?)
3(?)
3(?)
3
cefepime
3
3
3
3
3
3
3
3(?)
3(?)
3(?)
3
Aminoglycosides
---
---
---
---
---
---
---
---
---
---
---
gentamicin / tobramycin
2
2
2
2
2
2
3
3
3
3
3
amikacin
2
2
2
2
2
2
3
3
3
3
3
Macrolides
---
---
---
---
---
---
---
---
---
---
---
erythromycin
1
1
1
1
1
1
1
1
1
1
1
clarithromycin
2
2
2
2
2
2
1
1
1
1
1
azithromycin
2
2
2
2
3
2
1
1
1
1
1
dirithromycin
1
1
1
2
2
1
1
1
1
1
1
telithromycin
1
1
2
3
3
1
1
1
1
1
1
clindamycin
1
1
1
1
1
1
1
1
1
1
1
Tetracyclines
---
---
---
---
---
---
---
---
---
---
---
tetracycline / doxycycline
2
2
2
2
2
2
3
3
3
3
3
tigecycline
.
.
.
.
.
.
.
.
.
.
.
Carbapenems
---
---
---
---
---
---
---
---
---
---
---
ertapenem
3
3
3
3
3
3
3
3?
3?
3?
3?
meropenem
3
3
3
3
3
3
3
3?
3?
3?
3?
imipenem
3
3
3
3
3
3
3
3?
3?
3?
3?
Misc.
---
---
---
---
---
---
---
---
---
---
---
metronidazole
1
1
1
1
1
1
1
1
1
1
1
aztreonam
3
3
3
3
3
3
3
3?
3?
3?
3
colistin
.
.
.
.
.
.
.
.
.
.
.
rifampin
.
prophylaxis
.
.
.
.
.
.
synergy
.
.
rifaximin
.
.
.
.
.
.
.
.
.
.
.
trimethoprim/sulfamethoxisole
1
2
2
2
2
2
2
1
1
1
1
vancomycin
1
1
1
1
1
1
1
1
1
1
1
quinupristin/dalfopristin
1
1
1
1
1
1
1
1
1
1
1
linezolid
1
1
1
1
1
1
1
1
1
1
1
daptomycin
1
1
1
1
1
1
1
1
1
1
1
Quinolones
(8)
1
 
levofloxacin
2
3
3
3
3
3
3?
3?
3?
3?
3?
moxifloxacin /gatifloxacin
2
3
3
3
3
3
3?
3?
3?
3?
3?
ciprofloxacin
2
3
3
3
3
3
3?
3?
3?
3?
3?

 

3= great. Use an antibiotic empirically if it is a 3.

2.5 = the best we got, but I sure wish we had better. OK to use empirically as we do not have any other choice.

2= adequate if susceptible, use with caution (ie know what you are doing and local susceptibility patterns) but do not rely on it empirically if you do not have susceptibilities.

1.5 = if it is susceptible its great, but is almost never susceptible.

1= no way dude. You want a dead patient?

R = resistant

"?" = looks good in a test tube

"." = placeholder pending data

Notes:

(7) Use spectinomycin.

(8) Not endocarditis.