Dosing
CrCl > 80: 1 - 2 g iv q 4 h.
CrCl 80-50: 1 - 2 g iv q 4 h.
CrCl 50-10: 1 - 2 g iv q 4 h.
CrCl < 10: 1 - 2 g iv q 4 h.
Hemodialysis: 1 - 2 g iv q 4 h.
Peritoneal dialysis:
Important side effects
Interstitial nephritis and bone marrow suppression.
Important drug interactions
Cyclosporine, nifedipine, warfarin.
Rants and Screeds
Pearls
It is hard on peripheral veins which is why I use cefazolin for uncomplicated cellulitis. Interchangeable with oxacillin.
Treatment of choice
Arthritis, Brodie's abscess, Cellulitis, Endocarditis, Impetigo, Meningitis, Osteomyelitis, Pneumonia, surgical prophylaxis.
Use for
All gram-positive cocci except the enterococcus.
Don't use for
Class
Penicillin.
Last update 11/29/19