Infectious Disease Compendium

Halofantrine (Halfan®)

Not available in the UK or U.S.

Dosing

CrCl Formula

CrCl > 80: 500 mg po q 6 x 3d; may need to be repeated in a week.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Long qt and ventricular arrhythmias.

Important drug interactions

Antipsychotics, arsenic trioxide, astemizole, aurothioglucose, bepridil, chloral hydrate, chloroquine, chlorpromazine, cisapride, clarithromycin, class i antiarrhythmic agents, class ia antiarrhythmic agents, class iii antiarrhythmic agents, cotrimoxazole, dolasetron, droperidol, enflurane, erythromycin, erythromycin/sulfisoxazole, fluconazole, fluoxetine, foscarnet, gemifloxacin, halothane, isoflurane, isradipine, itraconazole, levomethadyl, lidoflazine, mefloquin, mesoridazine, octreotide, pentamadine, pimozide, probucol, prochlorperazine, spiramycin, sulfamethoxazole, telithromycin, telithromycin, thioridazine, tricyclic antidepressants, trifluoperazine, trimethoprim, vasopressin, venlafaxine, ziprasidone, zolmitriptan.

Rants and Screeds

Pearls

Do not take with grapefruit.

Treatment of choice

Use for

P. falciparum and P. vivax.

Don't use for

Class

Last update 11/27/19