Dosing
CrCl > 80: 400 mg po q 12 -24 h.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Diarrhea, nausea, dizziness, headache, peripheral neuropathy, qt interval prolongation (rare), severe hypersensitivity reactions (rare), tendon rupture (rare). Maybe retinal detachment (PubMed).
Important drug interactions
Antacids, antidiabetic agents, cisapride, class ia antiarrhythmic agents, class iii antiarrhythmic agents, corticosteroids, iron, mesoridazine, phenothiazines, sucralfate, thioridazine, tricyclic antidepressants, zinc, ziprasidone.
Rants and Screeds
Pearls
As with all quinolones, antacids bind the drug to prevent absorption.
Treatment of choice
Use for
Arthritis, Bronchitis, Cellulitis, Cholangitis and Cholecystitis, Cystic fibrosis, Endophthalmitis - postoperative, Gonorrhea, gynecologic infections, Helicobacter pylori - triple therapy, Legionella, Leprosy, Malaria, Meningitis, Neutropenic fever, Osteomyelitis, Pancreatitis, Peritonitis, Pneumonia, Prostatitis,Q fever, Salmonella, Typhoid fever, UTI.
Don't use for
Class
Quinolone.
Last update 11/30/19