Dosing
CrCl > 80: 100 mg po q 12 h.
CrCl 80-50: 100 mg po q h.
CrCl 50-10: do not use.
CrCl < 10: do not use.
Hemodialysis:
Peritoneal dialysis:
Important side effects
Retroperitoneal and pulmonary fibrosis. I see no reason to ever use this drug long term unless you want your ass sued off. There are plenty of other antibiotics available. My advice: do not use long term.
Anorexia, nausea, vomiting, headache, hemolytic anemia, hepatitis, cholestatic jaundice, hepatic necrosis (rare), peripheral neuropathy (rare, can be severe and irreversible (PubMed)).
Important drug interactions
Rants and Screeds
Don't use it long term. Ever. Never. It causes retroperitoneal fibrosis and only works if CrCl > 50, which is probably no one over age 65. Hint: CrCl declines with age.
Pearls
Treatment of choice
Use for
UTI.
Don't use for
Class
Curious Cases
Relevant links to my Medscape blog
Last update 11/29/19