(dosing from PDR)
Not available in US since 2012.
Dosing
CrCl > 70: 5 mg/kg q 12 IV; 1 gm po tid.
CrCl 69-50: 2.5 mg/kg q 12 h iv; 1.5 gm po qd.
CrCl 49-25: 2.5 mg/kg q 24 iv; 1 gm po qd.
CrCl 24 - 10: 1.25 mg/kg iv; 0.5 gm po qd.
CrCl < 10: 1.25 mg kg iv 3x wk; 0.5 g po 3x wk.
Hemodialysis:
Peritoneal dialysis:
Important side effects
Cytopenias, anemia, neutropenia (common), thrombocytopenia, anorexia, fever, phlebitis.Important drug interactions
Didanosine, imipenem, mycophenolate mofetil, mycophenolate sodium, mycophenolic acid, probenecid, tacrolimus, zidovudine.
Rants and Screeds
Pearls
Treatment of choice
Use for
CMV.
Don't use for
Class
Acyclic nucleoside.
Last Update 11/26/19