Infectious Disease Compendium

Cephapirin (Cefadyl®)

Dosing

CrCl Formula

CrCl > 80: 500 mg - 2.0 g q 4 - 6 h iv.

CrCl 80-50: 500 mg - 2.0 g q 6 h iv.

CrCl 50-10: 500 mg - 2.0 g q 8 h iv.

CrCl < 10: 500 mg - 2.0 g q 12 h iv.

Hemodialysis: 7.5 - 15 mg/kg before, then q 12 h.

Peritoneal dialysis: na.

Important side effects

Important drug interactions

Rants and Screeds

Pearls

Treatment of choice

Use for

No longer used in the US for humans, evidently still available for cattle.

Cellulitis, Endocarditis, Pneumonia, Osteomyelitis, Peritonitis, preoperative prophylaxis, UTI.

Don't use for

Class

First-generation cephalosporin.

Last Update: 08/27/19.