CrCl > 80: 1 -2 gm iv q 4 h.
CrCl 80-50: 1 -2 gm iv q 4 h.
CrCl 50-10: 1 -2 gm iv q 4 h.
CrCl < 10: 1 -2 gm iv q 4 h.
Hemodialysis: 1 -2 gm iv q 4 h.
Peritoneal dialysis:
Important side effects
Allergic hepatitis, nephritis and marrow suppression.
Important drug interactions
Ethinyl estradiol, mestranol, norelgestromin, norethindrone, norgestrel.
Rants and Screeds
Pearls
It is hard on peripheral veins which is why I use cefazolin for uncomplicated cellulitis.
Treatment of choice
S. aureus. Interchangeable with nafcillin. Arthritis, Cellulitis, Osteomyelitis, Pneumonia, surgical prophylaxis.
Use for
Streptococci.
Don't use for Enterococci.
Class
Penicillin.
Last update 11/30/19