Usually given in combination with trimethoprim (aka Bactrim® or Septra®).
Dosing
CrCl > 80: 500 mg - 1 g po q 6 - 8 h.
Important side effects
Allergic reactions, blood dyscrasias, crystalluria, renal failure (AIDS patients), diarrhea, nausea, severe hypersensitivity.
Important drug interactions
Acetohexamide, chlorpropamide, cyclosporine, fosphenytoin, glipizide, para-aminobenzoic acid (paba) and paba derivatives, phenytoin, tolazamide, tolbutamide.
Rants and Screeds
Pearls
Treatment of choice
Use for
Toxoplasma, Malaria, Rheumatic Fever - prophylaxis.
Don't use for
Class
Sulfonamide.
Last update 11/30/19