Dosing
CrCl > 80: Patients 12 years of age or older with diarrhea due to Giardia lamblia 500 mg o q 12 hours with food for 3 days. Clostridium difficile: 250 mg 4 times per day for 10 days or 500 mg 2 times per day for 10 days is as effective as metronidazole.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
The usual hodgepodge of gi complaints.
Important drug interactions
Rants and Screeds
Pearls
Treatment of choice
Use for
Cryptosporidium and Giardia lamblia. Also Clostridium difficile in adults.
600 mg twice daily for 5 days was associated with a decrease in the duration of symptoms in patients with acute uncomplicated influenza by about a day (PubMed). Or maybe not "Treatment with NTZ did not reduce the duration of hospital stay in severe influenza-like illness. Further analyses based on age and evaluations by virus did not reveal any subgroups that appeared to benefit from NTZ (Pubmed)."
Don't use for
Class
Last update 11/29/19