As of 4/11/19 not approved, but being fast-tracked
Dosing
CrCl > 400 mg po bid.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Dysgeusia: distortion of the sense of taste.
Important drug interactions
Rants and Screeds
Pearls
Treatment of choice
Use for
CMV. It is as good as ganciclovir in transplant patients with less bone marrow suppression but more gi upset (PubMed).
Don't use for
Class
Inhibits of an HCMV encoded protein kinase enzyme called UL97 or pUL97, blocking nuclear egress of viral capsids.
Last update 11/29/19