Infectious Disease Compendium

Comparison of Antibacterials

 

Gram-negative Rods

Penicillins
penicillin
1
1
1
1
1
1
1
1
1
1
ampicillin/amoxicillin
2
2
2
2
2
2
2
2
2
2
amoxicillin/clavulanate
2
2
2
2
2
2
2
2
2
2
ampicillin/sulbactam
2
2
2
2
2
2
2
2
2
2
nafcillin/oxacillin /dicloxacillin
1
1
1
1
1
1
1
1
1
1
mezlocillin/ piperacillin
2
2
2
2
2
2
2
2
2
2
ticarcillin/clavulanate
2
2
2
2
2
2
2
2
2
2
piperacillin/tazobactam
2
2
2
2
2
2
2
2
2
2
Cephlosporins
---
---
---
---
---
---
---
---
---
---
cefazolin / cephalexin
1
3
1
1
1
1
1
1
1
1
2nd genration: eg cefuroxime
2
2
1
1
1
1
1
1
1
1
cefotaxime / ceftriaxone
3
3
3
3
2
2
2
1
1
1
ceftazadime
3
3
3
3
3
3
3
3
3
3
cefepime
3
3
3
3
3
3
3
3
3
3
Aminoglycosides
---
---
---
---
---
---
---
---
---
---
gentamicin / tobramycin
3
3
3
3
3
3
3
3
3
3
amikacin
3
3
3
3
3
3
3
3
3
3
Macrolides
---
---
---
---
---
---
---
---
---
---
erythromycin
1
1
1
1
1
1
1
1
1
1
clarithromycin
1
1
1
1
1
1
1
1
1
1
azithromycin
1
1
1
1
1
1
1
1
1
1
dirithromycin
1
1
1
1
1
1
1
1
1
1
telithromycin
1
1
1
1
1
1
1
1
1
1
clindamycin
1
1
1
1
1
1
1
1
1
1
Tetracyclines
---
---
---
---
---
---
---
---
---
---
tetracycline / doxycycline
2
1
1
1
1
1
1
1
1
1
tigecycline
2.5
2.5
.
.
.
.
.
.
.
.
Carbapenems
---
---
---
---
---
---
---
---
---
---
ertapenem
3
3
3
3
3
3
3
1
1
1
doripenam
3
3
3
3
3
1.5
3
3
   
meropenem
3
3
3
3
3
3
3
3
2
2
imipenem
3
3
3
3
3
3
3
3
2
2
Misc.
---
---
---
---
---
---
---
---
---
---
metronidazole
1
1
1
1
1
1
1
1
1
1
aztreonam
3
3
3
3
3
3
3
3
3
3
colistin
2
2
2
2
2
2
1
2
2
1
rifampin
.
.
.
.
.
.
.
.
.
.
rifaximin
3(10)
.
.
.
.
.
.
.
.
.
trimethoprim/sulfamethoxisole
2
2
2
2
1
1
1
1
2
1
vancomycin
1
1
1
1
1
1
1
1
1
1
quinupristin/dalfopristin
1
1
1
1
1
1
1
1
1
1
linezolid
1
1
1
1
1
1
1
1
1
1
daptomycin
1
1
1
1
1
1
1
1
1
1
Quinolones
---
---
---
---
---
---
---
---
---
---
levofloxacin
3
3
3
1.5
3
3
3
2
3
3
moxifloxacin /gatifloxacin
3
3
3
1.5
2
2
2
2
3
3
ciprofloxacin
3
3
3
1.5
3
3
3
3
3
3

 

3= great. Use an antibiotic empirically if it is a 3.

2.5 = the best we got, but I sure wish we had better. OK to use empirically as we do not have any other choice.

2= adequate if susceptible, use with caution (ie know what you are doing and local susceptibility patterns) but do not rely on it empirically if you do not have susceptibilities.

1.5 = if it is susceptible its great, but is almost never susceptible.

1= no way dude. You want a dead patient?

R = resistant

"?" = looks good in a test tube

"." = placeholder pending data

Notes:

(10) No systemic absorbtion, use for GI illness only.