Infectious Disease Compendium

Baloxavir (Xofluza)

Dosing

CrCl Formula

CrCl > 80: 40 mg once, if > 80 kg, 80 mg once.

Important side effects

GI Upset.

Financial: $150.

Important drug interactions

Rants and Screeds

Pearls

Patients get better about a day faster. Give within 48, or even better, 24 hours of onset of symptoms.

Treatment of choice

Use for

Influenza A and B. May be better than olsetamivir for B (PubMed). It inhibits A>B>C>D and a variety of animal influenzas (PubMed).

Class

Blocks influenza replication by inhibition of viral endonuclease.

Last Update: 08/03/19.