Infectious Disease Compendium

Plazomicin

(Review)

Dosing

CrCl Formula

CrCl > 60: 15 mg per kilogram daily.

CrCl ≥30 to 60 mL/min: 10 mg/kg IV q 24 hr .

CrCl ≥15 to 30 mL/min: 10 mg/kg IV q 48 hr.

Hemodialysis:

Peritoneal dialysis:

Important side effects

Oto and nephrotoxicity.

Important drug interactions

Rants and Screeds

Pearls

Resistant to most aminoglycoside-modifying enzymes.

Treatment of choice

Use for

CRE E. coli and K. pneumoniae UTI (PubMed) and bloodstream infections (PubMed).

So-so for Pseudomonas aeruginosa and Acinetobacter baumannii, same as any other aminoglycoside.

Don't use for

Proteus mirabilis, Providencia, and Morganella morganii. Or Stenotrophomonas maltophilia.

Class

Aminoglycoside. "Plazomicin is an aminoglycoside that is engineered to evade modification by aminoglycoside- modifying enzymes, and it maintains activity in the presence of most mechanisms that lead to resistance in Enterobacteriaceae, including mutations in sites targeted by fluoroquinolones and the production of aminoglycoside-modifying enzymes, extended-spectrum β-lactamases, and carbapenemases (PubMed)."

Last update 02/16/20