Dosing
CrCl > 80: 45 mg/m2 iv q d.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Nausea, vomiting, stomatitis, hepatotoxicity, myelosuppression, rash, renal toxicity.
Important drug interactions
Use with folinic acid 20 mg/m2 po or iv q 6. Cimetidine, clotrimazole, erythromycin, fluconazole, itraconazole, ketoconazole, miconazole, rifabutin, rifampin.
Rants and Screeds
Pearls
Treatment of choice
Use for
Pneumocystis carinii as a last-ditch therapy.
Don't use for
Class
Last update 11/30/19