Infectious Disease Compendium

Peramivir (Rapivab)

CrCl Formula

CrCl > 80: 600 mg IV. Usually just once and it cost a cool grand.

CrCl 30-49 mL/min: 200 mg IV as a single dose/p>

CrCl 10-29 mL/min: 100 mg IV as a single dose

Important side effects

Low wbc, increase glucose and, of course, diarrhea.

Important drug interactions

Rants and Screeds

What the hell is your patient getting influenza for anyway? Haven't you heard of the vaccine, bub?

Pearls

92% of influenza is now resistant to amantadine and rimantadine; only useful if given within the first 72 hours of illness and shortens the illness by a day or so. Given how awful influenza is, it's probably worth it.

Treatment of choice

Use for

Influenza A and B.

It is no worse than oseltamivir but it costs a tonne. (PubMed).

Don't use for

Class

Neuraminidase inhibitor

Last update 11/30/19