Infectious Disease Compendium

Isavuconazole (Cresemba®)

2015 Review. The brand name sounds like a Lion King Character.

Dosing

CrCl Formula

CrCl > 80: a loading dose of 600 mg, given as 200 mg every 8 hours, for 2 days followed by 200 mg daily.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Important drug interactions

Rifampin will decrease drug levels.

Rants and Screeds

Pearls

Treatment of choice

Use for

Cryptococcus, Paracoccidioides, Coccidioides, Histoplasma, and Blastomyces (Pubmed) have been successfully treated.

Aspergillus and Mucormycosis have the most experience; it has good mics against a wide range of fungi but few clinical trials, see the above review.

Don't use for

May want to avoid as prophylaxis in heme malignancy, as of 2020 more breakthrough fungal infections, especially with Aspergillus (Pubmed).

Class

Azole.

Last update 02/29/20