Dosing
CrCl > 80: (Toxoplasma treatment)
<60 kg: 1 g po q 6 hours plus pyrimethamine 50 mg po qd.
>=60 kg: Sulfadiazine 1500 mg po q 6 hours plus pyrimethamine 75 mg po qd.
Add leucovorin 10 to 20 mg/day orally (may increase up to 50 mg/day).
Important side effects
Allergic reactions, blood dyscrasias, crystalluria, renal failure (AIDS patients), diarrhea, nausea, severe hypersensitivity.
Important drug interactions
Rants and Screeds
Pearls
Treatment of choice
Use for
Toxoplasma, in combination, sulfadiazine, and pyrimethamine.
Don't use for
Class
Sulfonamide.
Last update 11/30/19