Dosing
CrCl > 80: 10 mg/kg
Important side effects
Increased risk of heart failure in patients with pre-existing congestive heart failure.
Important drug interactions
Rants and Screeds
Costs a fortune, almost 4 grand a vial. Curiously, those who make the product think it is cost-effective. What a surprise.
Pearls
Treatment of choice
Prevents C. difficile recurrence in patients with 1 or more of the following risks: age > 65 years, history of CDI, immunocompromised, or severe CDI.
Use for
C. difficile recurrence in high-risk patients. The absolute reduction is 12-19%, depending on the study methodology (PubMed).
Class
Monoclonal antibody against anti-toxin B.