Dosing
CrCl > 80: 1 mg/kg iv every 12 hours.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
None unique.
Important drug interactions
Rifampin (decreases) and itraconazole (increases).
Rants and Screeds
Pearls
Mostly static against gram-positives, it can kill some Escherichia coli and Klebsiella pneumoniae. It may be useful for some CRE and ESBL.
Treatment of choice
Use for
Gets all the usual colon organisms: streptococci, anaerobes, and gnb.
Approved for complicated intra-abdominal infections, where it is no worse than meropenem, including those with ESBL (Pubmed). But. All patients had source control so probably anything would have worked.
Don't use for
UTI.
Class
A fancy-schmancy tetracycline.
Last Update: 11/20/19.