Dosing
CrCl > 80: 1 gm po q 6.
CrCl 80-50: 1 gm po q 6.
CrCl 50-10: 1 gm po q 6.
CrCl < 10: do not use.
Hemodialysis:
Peritoneal dialysis:
Important side effects
Coma, diarrhea, dizziness, drowsiness, headache, hemolytic anemia, metabolic acidosis, n/v, peripheral neuropathy, photosensitivity, psychotic reactions, qt interval prolongation, rash, seizures, tendon rupture.
Important drug interactions
Antacids, cyclosporine, didanosine, disopyramide, melphalan, pirmenol, prajmaline, procainamide, quinidine, sucralfate, warfarin.
Rants and Screeds
Pearls
Treatment of choice
Use for
Don't use for
Class
Affects bacterial DNA topoisomerase, the precursor of the quinolones we all know and love.
Last update 11/29/19