Dosing
CrCl > 80: 1-2 gm q 6-8 h iv.
CrCl 80-50: 1-2 gm q 8-12 h iv.
CrCl 50-10: 1-2 gm q 12-24 h iv.
CrCl < 10: 500 mg - 1 gm q 12-48 iv.
Hemodialysis: 1-2 g after dialysis.
Peritoneal dialysis:
Important side effects
Important drug interactions
Rants and Screeds
Pearls
Treatment of choice
Use for
A second generation with reasonable anaerobic coverage. Arthritis, Cellulitis, Diverticulosis/itis, Endometritis, Intraabdominal infections, Osteomyelitis, PID, surgical prophylaxis, UTI.
It can be used to treat ESBL E. coli (PubMed) GU infections.
Some atypical mycobacteria.
Don't use for
Class
Second-generation cephalosporin, technically a cephamycin.
Last Update: 08/06/19.