Infectious Disease Compendium

Cidofovir (Vistide®)

Dosing

CrCl Formula

CrCl > 55: 5 mg/kg q wk x 2.

Probenecid may be administered at 2 grams 3 hr prior and one gram administered at 2 hr after and again at 8 hr after each cidofovir infusion (for a total of 4 grams).

Probenecid may decrease overall toxicity.

Also a liter of IV fluids with each dose.

Contraindicated with CrCl < 55 or creat > 1.5 or > 100 mg proteinuria.

Hemodialysis:

Peritoneal dialysis:

Important side effects

Nephrotoxic, neutropenia, uveitis and Fanconi's syndrome (inadequate reabsorption in the proximal renal tubules).

Important drug interactions

Avoid other nephrotoxins (aminoglycosides, pentamidine).

Rants and Screeds

Pearls

Treatment of choice

Use for

CMV retinitis in AIDS, acyclovir-resistant Herpes simplex (one time dose).

Maybe BK virus.

Don't use for

Class

Acyclic nucleoside phosphonate, it inhibits DNA polymerase, viral >>> human.

Last Update: 09/03/19.