Dosing
For up-to-date information, go to http://hivinsite.ucsf.edu/tables.
CrCl > 80: 3 po bid.
Concomitant nevirapine or efavirenz: 533/133 mg (4 capsules or 6.5mL) po bid.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Asthenia, headache, diabetes mellitus (new onset or exacerbation), hyperglycemia, diarrhea, nausea, elevations in total cholesterol and triglycerides, fat redistribution (less common), hepatotoxicity, pancreatitis.
Important drug interactions
Acenocoumarol, alfuzosin, alprazolam, amiodarone, amprenavir, aprepitant, astemizole, atazanavir, atorvastatin, bepridil, bupropion, cannabis, carbamazepine, cerivastatin, cisapride, clarithromycin, clonazepam, clorazepate, clozapine, cyclosporine, dalfopristin, darifenacin, desipramine, dexamethasone, diazepam, didanosine, digoxin, diltiazem, disopyramide, dronabinol, dutasteride, eletriptan, encainide, ergot derivatives, erlotinib, estazolam, eszopiclone, ethinyl estradiol, ethosuximide, fentanyl, flecainide, fluoxetine, flurazepam, fluticasone, fusidic acid, garlic, imipramine, indinavir, itraconazole, ketoconazole, lamotrigine, levonorgestrel, levothyroxine, lidocaine, lovastatin, meperidine, mestranol, methadone, methylenedioxymethamphetamine, metoprolol, mexiletine, midazolam, nefazodone, nelfinavir, nifedipine, norelgestromin, norethindrone, norgestrel, olanzapine, phenytoin, pimozide, prednisone, propafenone, propoxyphene, quinidine, quinine, quinupristin/dalfopristin, rifabutin, rifampin, rifapentine, risperidone, saquinavir, sildenafil, simvastatin, st john's wort, tacrolimus, tadalafil, tenofovir, terfenadine, theophylline, thioridazine, timolol, tipranavir, tramadol, trazodone, triazolam, vardenafil, verapamil, voriconazole, warfarin, zidovudine, zolpidem.
Rants and Screeds
Pearls
Treatment of choice
Use for
Don't use for
Class
Protease inhibitor.
Last update 11/28/19