Dosing
CrCl > 80: 37 mg/kg q 6-hours.
CrCl 80-50: 6h.
CrCl 50-10: 12-24h.
CrCl < 10: 15-25 mg/kg q24h.
Hemodialysis:
Peritoneal dialysis:
Important side effects
Toxic megacolon and cytopenias.
Important drug interactions
Amphotericin B liposome, cytarabine, levomethadyl, zidovudine,
Rants and Screeds
Pearls
Keep blood levels between 20 and 100 micrograms per ml.
In 2016 it is $2000 a DAY, part of ongoing price gouging and profiteering.
Treatment of choice
Use for
Used synergistically with amphotericin B against Candida and Cryptococcus.
Last update 11/25/19