Dosing
CrCl Formula
CrCl > 80: 1 - 2 g iv q 6 - 12 h.
CrCl 80-50: 1 - 2 g iv q 6 - 12 h.
CrCl 50-10: 1 - 2 g iv q 6 - 12 h.
CrCl < 10: 1 - 2 g iv q 6 - 12 h.
Hemodialysis: dose after dialysis
Peritoneal dialysis:
Important side effects
Hypoprothrombinemia with an increase in the protime.
Important drug interactions
Heparin, warfarin due to hypoprothrombinemia with an increase in the protime.
Rants and Screeds
Pearls
No longer available in the US.
Treatment of choice
Use for
Anything you would use a third-generation cephalosporin for Cellulitis, Cholangitis, Cholecystitis, Gonorrhea, Intraabdominal infections, PID, Peritonitis, Pneumonia, Meningitis, ocular infections, Osteomyelitis, Otitis media, peritoneal dialysis, Peritonitis, Proteus mirabilis infections, Pneumonia, Sepsis, UTI.
Don't use for
Class
Third-generation cephalosporin.
Last Update: 08/05/19.