CrCl Formula CrCl > 80: 650 mg po q 8 h.
Important side effects
Disseminated intravascular coagulation, hemolytic uremic syndrome, hepatotoxicity, hypoglycemia, interstitial nephritis, nausea/vomiting, dysphagia, epigastric pain, ototoxicity (rare, reverses when drug stopped), thrombocytopenia.
Important drug interactions
Astemizole, aurothioglucose, cyclosporine, dicumarol, digoxin, droperidol, mefloquine, metformin, pancuronium, rifampin, rifapentine, ritonavir, saquinavir, warfarin.
Rants and Screeds
(: combine with gin for a gin and tonic:).
Pearls
Check for glucose-6-phosphate dehydrogenase deficiency, which, being protective for malaria, they should not have. G6P that is.
Treatment of choice
Use for
Don't use for
Class
Last update 11/30/19