Infectious Disease Compendium

Bedaquiline

Dosing

CrCl Formula

CrCl > 80: 400 mg a day for two weeks and then 200 mg taken three times a week (with at least 48 hours between doses) for the next 22 weeks

CrCl 80-50: 400

CrCl 50-10:

CrCl <10: na

Hemodialysis : no data.

Peritoneal dialysis: no data.

Important side effects

Common: gastrointestinal (nausea, vomiting, diarrhea, abdominal pain), arthralgias headaches, and chest pain, QT prolongation, liver dysfunction.

Important drug interactions

Rants and Screeds

Pearls

When resistance occurs, which it has, it has cross resistance with clofazamine.

Use for

MDR Mycobacterium tuberculosis.

Treatment of choice

Don't use for

Class

Diarylquinoline. It blocks the ability of M. tuberculosis to make adenosine 5'-triphosphate (ATP).

Last Update: 05/19/18.