Dosing
CrCl > 80:
Loading Dose | Maintenance | |
CAP | Day 1: 100-200 mg iv | 100 mg iv or 300 mg po qd |
Cellulitis | 100-200 mg iv | 100 mg iv or 300 mg po qd |
Cellulitis Oral | Day 1 and 2: 450 mg po qd | 300 mp po qd |
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
None unique. 6 150mg tabs cost $1250, so bankruptcy is a risk.
Important drug interactions
Rants and Screeds
Pearls
Treatment of choice
Use for
Approved for CAP (but a higher mortality (2%) rate than moxifloxacin comparator (1%))(PubMed) and cellulitis (PubMed) (PubMed).
Mostly an anti gram-positive antibiotic.
"It is active against most gram-positive organisms, including MRSA, coagulase-negative Staphylococcus, vancomycin-resistant Enterococcus, Streptococcus pyogenes, and S. pneumoniae, and including those resistant to tetracycline...(PubMed)".
Some ESBL E. coli and K. pneumoniae.
Don't use for
Class
A fancy-schmancy tetracycline.
Last update 11/30/19