Dosing
For up-to-date information, go to http://hivinsite.ucsf.edu/tables.
CrCl > 80: 600 mg - 1.2 g po q 8 h. Saquinavir (soft gel capsule) 1200 mg po tid.
HIV infection: (with low-dose ritonavir) saquinavir (soft gel capsule) 1000 mg and ritonavir 100 mg po bid OR saquinavir (soft gel capsule) 400 mg and ritonavir 400 mg po bid.
Important side effects
Abdominal discomfort, diarrhea, dyspepsia, nausea, asthenia, diabetes mellitus, hyperglycemia, fat redistribution.
Important drug interactions
Alfentanil, alfuzosin, alprazolam, amiodarone, amlodipine, amprenavir, astemizole, atazanavir, atorvastatin, bepridil, bitter orange, carbamazepine, cerivastatin, cimetidine, cisapride, clarithromycin, cyclosporine, dapsone, delavirdine, dexamethasone, diltiazem, disopyramide, efavirenz, eletriptan, ergot derivatives, erlotinib, felodipine, fentanyl, flecainide, flunarizine, fosamprenavir, fosphenytoin, fusidic acid, gallopamil, indinavir, isradipine, itraconazole, ketoconazole, lacidipine, levomethadyl, lovastatin, midazolam, nelfinavir, nevirapine, nicardipine, nifedipine, nilvadipine, nimodipine, nisoldipine, nitrendipine, phenobarbital, phenytoin, pimozide, propafenone, quinidine, quinine, rifabutin, rifampin, rifapentine, ritonavir, sildenafil, simvastatin, sirolimus, st john's wort, tacrolimus, tadalafil, terfenadine, triazolam, vardenafil, verapamil, voriconazole, warfarin.
Rants and Screeds
Pearls
Usually used to boost other HIV medications, see HIV for more information.
Treatment of choice
Use for
HIV.
Don't use for
Class
Protease inhibitor.
Last update 11/30/19