Dosing
CrCl Formula
CrCl > 80: 1 - 2 g iv q 6 - 12 h.
CrCl 80-50: 1 - 2 g iv q 12 h.
CrCl 50-10: 1 - 2 g iv q 16 - 24 h.
CrCl < 10: 1 -2 g iv q 48 h.
Hemodialysis:
Peritoneal dialysis:
Important side effects
Increase in prothrombin time.
Important drug interactions
Rants and Screeds
Pearls
Like all cephamycins, better anaerobic spectrum and stable to ESBL.
Treatment of choice
Use for
Appendicitis, Cellulitis, Cholangitis, Cholecystitis, chronic Bronchitis, Intraabdominal infections, PID, Peritonitis, Pneumonia, surgical prophylaxis (its main use), UTI.
Don't use for
Class
Second-generation cephalosporin, a cephamycin.
Last update: 07/24/19