Dosing
CrCl > 80: 250 mg once a week for prevention; 1250 mg x 1 for treatment.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Psychosis and really weird and disturbing dreams. Like Trump as president. Actually reality is worse than a dream. Also diarrhea, dizziness, drowsiness, extrasystoles, nausea, psychiatric symptoms, seizures (rare), sinus bradycardia, vomiting (3%).
Important drug interactions
Antipsychotics, arsenic trioxide, astemizole, aurothioglucose, bepridil, carbamazepine, chloral hydrate, chloroquine, cisapride, clarithromycin, class i antiarrhythmic agents, class ia antiarrhythmic agents, class iii antiarrhythmic agents, cotrimoxazole, dolasetron, droperidol, enflurane, erythromycin, erythromycin/sulfisoxazole, fluconazole, fluoxetine, foscarnet, gemifloxacin, halofantrine, halothane, isoflurane, isradipine, levomethadyl, lidoflazine, lumefantrine, mesoridazine, octreotide, pentamidine, phenobarbital, phenothiazines, phenytoin, pimozide, probucol, propranolol, quinidine, quinine, rifampin, spiramycin, sulfamethoxazole, telithromycin, terfenadine, thioridazine, trimethoprim, typhoid vaccine, live, valproic acid, vasopressin, venlafaxine, ziprasidone, zolmitriptan.
Rants and Screeds
Pearls
Treatment of choice
Use for
Malaria treatment and prophylaxis. Still, have to treat the hepatic phase with primaquine for P. vivax and P. ovale.
Don't use for
Class
Last update 11/29/19