Dosing
480 mg per day.
240 mg per day in patients taking cyclosporine.Hemodialysis:
Peritoneal dialysis:
Important side effects
Nausea, diarrhea, vomiting, edema of arms and legs, cough, headache, fatigue, and abdominal pain.
Important drug interactions
Do not take with pimozide or ergot alkaloids and if taken with cyclosporine, do not take pitavastatin or simvastatin.
Rants and Screeds
Pearls
Treatment of choice
Use for
CMV prophylaxis in allogeneic hematopoietic stem cell transplant patients (PubMed).
Don't use for
Class
CMV multiplication involves the cleaving of concatemeric genomic viral DNA and the packaging each genome into virus capsids, which is mediated by the CMV–terminase complex: UL51, UL56, and UL89. But you knew that. Letermovir inhibits CMV replication by binding to components of the terminase complex.
Last update 11/28/19