Infectious Disease Compendium

Delafloxacin

Dosing

CrCl Formula

CrCl > 29: 300mg iv q 12 h.

450 mg po q 12 h.

CrCl 80-50:

CrCl < 29 15–29 mL/min 200 mg IV, Q12h

Hemodialysis:

Peritoneal dialysis:

Important side effects

Usual quinolone issues. Maybe no QT prolongation issues.

Important drug interactions

As with all quinolones, oral divalent cations will bind the drug and prevent absorption.

Rants and Screeds

Treatment of choice

Use for

Approved for Cellulitis and Pneumonia.

It has better activity against S. aureus, including MRSA, and streptococci than other quinolones, including ciprofloxacin and levofloxacin strains.

E. coli and friends, the Enterobacteriaceae.

Active against anaerobes and atypical respiratory pathogens (Legionella and Mycoplasma).

Don't use for

Enterococcus faecium, extended-spectrum β-lactamase Enterobacteriaceae, ceftazidime-resistant Pseudomonas aeruginosa, and Acinetobacter.

Class

Quinolone.