Infectious Disease Compendium

Adefovir (Hepsera®)

Dosing

CrCl Formula

CrCl > 80:

Hepatitis B:

CrCl 50 or greater: 10 mg every 24 hours.

CrCl 20 to 49: 10 mg every 48 hours.

CrCl 10 to 19: 10 mg every 72 hours.

CrCl less than 10: no dosing recommendation.

CrCl hemodialysis: 10 mg every 7 days following dialysis.

Important side effects

Nephrotoxicity, decreases in phosphorus, hepatitis.

Lactic acidosis and severe hepatomegaly with steatosis with adefovir alone or with other antiretrovirals.

Use for

Hepatitis B (PubMed).

Use after a failure of lamivudine in e antigen positive patients.

Class

Acyclic nucleoside analog, it is a reverse transcriptase inhibitor.

Last Update: 03/27/19.