Infectious Disease Compendium

Tafenoquine

Dosing

CrCl Formula

CrCl > 80: 300 mg po single dose

Important side effects

Abdominal pain, hemolytic anemia (check for G6PD deficiency, which is protective against malaria, so they are likely negative), leukopenia, methemoglobinemia.

Important drug interactions

Rants and Screeds

Pearls

Maybe not as good as primaquine: "In the intention-to-treat population, the percentage of patients who were free from recurrence at 6 months was 62.4% in the tafenoquine group, 27.7% in the placebo group, and 69.6% in the primaquine group (PubMed)(PubMed)."

Treatment of choice

The liver phase of P. vivax.

Use for

Don't use for

Class

Last update 11/30/19