Infectious Disease Compendium

Nitazoxanide (Alinia®)

Dosing

CrCl Formula

CrCl > 80: Patients 12 years of age or older with diarrhea due to Giardia lamblia 500 mg o q 12 hours with food for 3 days. Clostridium difficile: 250 mg 4 times per day for 10 days or 500 mg 2 times per day for 10 days is as effective as metronidazole.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

The usual hodgepodge of gi complaints.

Important drug interactions

Rants and Screeds

Pearls

Treatment of choice

Use for

Cryptosporidium and Giardia lamblia. Also Clostridium difficile in adults.

600 mg twice daily for 5 days was associated with a decrease in the duration of symptoms in patients with acute uncomplicated influenza by about a day (PubMed).  Or maybe not "Treatment with NTZ did not reduce the duration of hospital stay in severe influenza-like illness. Further analyses based on age and evaluations by virus did not reveal any subgroups that appeared to benefit from NTZ (Pubmed)."

Don't use for

Class

Last update 11/29/19


(Pubmed)