Dosing
CrCl > 80: 600 mg base (1000 mg chloroquine phosphate) PO, then 300 mg base (500 mg salt) 6 hr later, and again on days 2 and 3.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
EKG changes, decrease in hearing, long term can lead to retinal degeneration and blindness as well as many other side effects.
Important drug interactions
WITH THE EXCEPTION OF antacids and kaolin, which decrease absorption, ALL OF THE FOLLOWING WILL INCREASE THE QT and could lead to cardiac death: antipsychotics, arsenic trioxide, astemizole, aurothioglucose, bepridil, chloral hydrate, chloroguanide, cimetidine, cisapride, clarithromycin, class i antiarrhythmic agents, class ia antiarrhythmic agents, class iii antiarrhythmic agents, cotrimoxazole, cyclosporine, dolasetron, droperidol, enflurane, erythromycin, erythromycin/sulfisoxazole, fluconazole, fluoxetine, foscarnet, gemifloxacin, halofantrine, halothane, isoflurane, isradipine, kaolin, levomethadyl, levothyroxine, lidoflazine, mefloquine, mesoridazine, octreotide, pentamidine, phenothiazines, pimozide, praziquantel, probucol, spiramycin, sulfamethoxazole, telithromycin, terfenadine, thioridazine, tricyclic antidepressants, trimethoprim, vasopressin, venlafaxine, ziprasidone, zolmitriptan.
Rants and Screeds
Pearls
Treatment of choice
Malaria. If sensitive. Many are not.
Use for
Don't use for
Class
4-aminoquinoline derivative.
Last Update: 09/03/19.