Infectious Disease Compendium

Eravacycline

Dosing

CrCl Formula

CrCl > 80: 1 mg/kg iv every 12 hours.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

None unique.

Important drug interactions

Rifampin (decreases) and itraconazole (increases).

Rants and Screeds

Pearls

Mostly static against gram-positives, it can kill some Escherichia coli and Klebsiella pneumoniae. It may be useful for some CRE and ESBL.

Treatment of choice

Use for

Gets all the usual colon organisms: streptococci, anaerobes, and gnb.

Approved for complicated intra-abdominal infections, where it is no worse than meropenem, including those with ESBL (Pubmed). But. All patients had source control so probably anything would have worked.

Don't use for

UTI.

Class

A fancy-schmancy tetracycline.

Last Update: 11/20/19.