Dosing
CrCl > 55: 5 mg/kg q wk x 2.
Probenecid may be administered at 2 grams 3 hr prior and one gram administered at 2 hr after and again at 8 hr after each cidofovir infusion (for a total of 4 grams).
Probenecid may decrease overall toxicity.
Also a liter of IV fluids with each dose.
Contraindicated with CrCl < 55 or creat > 1.5 or > 100 mg proteinuria.
Hemodialysis:
Peritoneal dialysis:
Important side effects
Nephrotoxic, neutropenia, uveitis and Fanconi's syndrome (inadequate reabsorption in the proximal renal tubules).
Important drug interactions
Avoid other nephrotoxins (aminoglycosides, pentamidine).
Rants and Screeds
Pearls
Treatment of choice
Use for
CMV retinitis in AIDS, acyclovir-resistant Herpes simplex (one time dose).
Maybe BK virus.
Don't use for
Class
Acyclic nucleoside phosphonate, it inhibits DNA polymerase, viral >>> human.