Dosing
For up-to-date information, go to http://hivinsite.ucsf.edu/.
CrCl > 80: 600 mg po qd.
There will be fewer side effects if you start slow: 200 mg first week, 400 mg the second then get to the 600 a day (PubMed).
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Rash and nightmares, neuropsychiatric, fat redistribution.
Important drug interactions
Alfuzosin, amprenavir, astemizole, atazanavir, carbamazepine, caspofungin, cisapride, clarithromycin, eletriptan, ergot derivatives, fosamprenavir, fosphenytoin, indinavir, lopinavir, methadone, midazolam, phenobarbital, phenytoin, rifabutin, rifampin, rifapentine, ritonavir, saquinavir, St John's wort, triazolam, voriconazole.
Rants and Screeds
Pearls
Treatment of choice
Use for
HIV.
Don't use for
Class
NNRTI: Non-Nucleoside Reverse Transcriptase Inhibitor
Last update 11/19/19