Dosing
CrCl > 80: 500 mg - 2 g q 4 - 8 h iv.
CrCl 80-50: 500 mg - 2 g q 6 h iv.
CrCl 50-10: 500 mg - 2 g q 8 h iv.
CrCl < 10: 500 mg - 1 g q 12 h iv.
Hemodialysis:
Peritoneal dialysis:
Important side effects
Important drug interactions
Heparin coagulation abnormalities due to a direct effect on prothrombin time or vitamin K production. Warfarin hypoprothrombinemia and/or prolonged bleeding time.
Rants and Screeds
Pearls
When I was a resident, 1983-1986, we had no third-generation cephalosporins, and this was the goto antibiotic for CAP. Mandol on call we would say. Does anyone use it anymore? It is no longer available in the US.
Treatment of choice
Use for
Arthritis, Osteomyelitis, Peritonitis, Pneumonia, surgical prophylaxis.
Don't use for
Class
Second-generation cephalosporin.
Last Update: 07/04/19