Dosing
For up-to-date information, go to http://hivinsite.ucsf.edu/tables.
CrCl > 80: 200 mg po q 12 h.
CrCl 80-50: 200 mg po q 12 h.
CrCl 50-10: 200 mg po q 12 h.
CrCl < 10: 200 mg po q 12 h.
Hemodialysis:
Peritoneal dialysis:
Important side effects
Headache, fatigue, diarrhea, nausea, fat redistribution, hepatitis (there is a genetic predisposition (PubMed) its MDR1 3435C to T if you are interested), hepatic failure, rash (very common can go to Stevens-Johnson syndrome, toxic epidermal necrolysis).
Important drug interactions
Amiodarone, amprenavir, atazanavir, carbamazepine, caspofungin, cisapride, clarithromycin, clonazepam, cyclophosphamide, cyclosporine, diltiazem, disopyramide, ergotamine, ethinyl estradiol, ethosuximide, etonogestrel, fentanyl, fluconazole, fosamprenavir, indinavir, itraconazole, ketoconazole, levonorgestrel, lidocaine, lopinavir, medroxyprogesterone, mestranol, methadone, nifedipine, norethindrone, norgestrel, quinupristin/dalfopristin, rifabutin, rifampin, rifapentine, saquinavir, sirolimus, St john's wort, tacrolimus, verapamil, voriconazole, warfarin.
Rants and Screeds
Pearls
Treatment of choice
Use for
HIV.Don't use for
Class
Non-nucleoside reverse transcriptase inhibitor (NNRTI).
Last update 11/29/19