Infectious Disease Compendium

Cefoxitin (Mefoxin®)

Dosing

CrCl Formula

CrCl > 80: 1-2 gm q 6-8 h iv.

CrCl 80-50: 1-2 gm q 8-12 h iv.

CrCl 50-10: 1-2 gm q 12-24 h iv.

CrCl < 10: 500 mg - 1 gm q 12-48 iv.

Hemodialysis: 1-2 g after dialysis.

Peritoneal dialysis:

Important side effects

Important drug interactions

Rants and Screeds

Pearls

Treatment of choice

Use for

A second generation with reasonable anaerobic coverage. Arthritis, Cellulitis, Diverticulosis/itis, Endometritis, Intraabdominal infections, Osteomyelitis, PID, surgical prophylaxis, UTI.

It can be used to treat ESBL E. coli (PubMed) GU infections.

Some atypical mycobacteria.

Don't use for

Class

Second-generation cephalosporin, technically a cephamycin.

Last Update: 08/06/19.