For up-to-date information, go to http://hivinsite.ucsf.edu/tables.
CrCl > 80: >60 kg or more 200 mg in tablet form or 250 mg of the powder formulation, po q 12 h.< 60 kg, 125 mg tablet or 167 mg powder po q 12 h.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Pancreatitis and peripheral neuropathy.
Lactic acidosis and hepatomegaly with steatosis and Noncirrhotic portal hypertension
Important drug interactions
Allopurinol, amprenavir, antacids, atazanavir, atevirdine, cinoxacin, ciprofloxacin, delavirdine, enoxacin, ganciclovir, gemifloxacin, grepafloxacin, hydroxyurea, indinavir, itraconazole, ketoconazole, levofloxacin, lomefloxacin, methadone, moxifloxacin, naladixic acid, nelfinavir, ofloxacin, ribavirin, ritonavir, stavudine, tenofovir, zalcitabine.
Rants and Screeds
Pearls
Treatment of choice
HIV.
Use for
Don't use for
Class
Reverse transcriptase inhibitor.
Last Update: 11/15/19