Infectious Disease Compendium

Lefamulin (Xenleta)

Dosing

CrCl Formula

CrCl > 80: 150 mg BID for IV and 600 mg BID po.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Liver enzyme elevation and prolongs QT interval.

Important drug interactions

Rants and Screeds

Pearls

Treatment of choice

Use for

CAP (FDA approved) (PubMed) and cellulitis.

Gram-positives: Streptococcus pneumoniae, Staphylococcus aureus [including MRSA], Enterococcus faecium [including VRE], coagulase negative staphylococci, beta-hemolytic streptococci, viridans group streptococci. Gram-negatives: Haemophilus influenzae, Neisseria gonorrhoeae, Moraxella catarrhalis. Atypicals: Mycoplasma pneumoniae, Legionella pneumophila, and Chlamydophila pneumoniae, Mycoplasma genitalium.

Don't use for

Class

Pleuromutilin antibiotic: inhibits bacterial protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, which prevents the binding of transfer RNA for peptide transfer.

Last Update: 10/16/19.