Mostly used as a topical antifungal.
Dosing
CrCl > 80: 400-1200 mg iv q 8 h.
CrCl 80-50: 400-1200 mg iv q 8 h.
CrCl 50-10: 400-1200 mg iv q 8 h.
CrCl < 10: 400-1200 mg iv q 8 h.
Hemodialysis:400-1200 mg iv q 8 h.
Peritoneal dialysis: 400-1200 mg iv q 8 h.
Important side effects
Important drug interactions
Acenocoumarol, anisindione, benzodiazepines, cyclosporine, dicumarol, fentanyl, fosphenytoin, glimepiride, phenindione, phenprocoumon, phenytoin, pimozide, tolterodine, trimetrexate, warfarin.
Rants and Screeds
Never used systemically anymore with the newer agents available.
Pearls
Treatment of choice
Use for
Topically for Candida vaginitis. Candidiasis - arthritic/mucocutaneous/ vaginitis, Coccidioidomycosis, dermatomycosis, diaper dermatitis, petriellidosis, tinea corporis, tinea infections, tinea nigra palmaris, tinea pedis, tinea versicolor, tinea versicolor.
Don't use for
Class
Imidazole.
Last update 11/29/19