Dosing
CrCl > 80: 500 mg po q 24.
CrCl 80-50: no change.
CrCl 50-10: no change.
CrCl < 10: no change.
Hemodialysis:
Peritoneal dialysis:
Important side effects
GI.
Important drug interactions
Cyclosporine, digoxin, dofetilide, ergot derivatives, fentanyl, pimozide.
Rants and Screeds
Pearls
Not available in the United States.
Treatment of choice
Use for
Nothing. It is less active against everything compared to erythromycin. So use erythromycin instead. Bronchitis, Cellulitis, COPD exacerbation, Pharyngitis, Pneumonia- community-acquired, tonsillitis.
Don't use for
Class
Macrolide.
Last update 11/16/19