Ceftazidime (Fortaz®, Tazicef®, Tazidime®)
Dosing
CrCl > 80: 1 - 2 g iv q 8 - 12 h iv.
CrCl 80-50: 1 - 2 g iv q 8 - 12 h iv.
CrCl 50-10: 1 - 2 g iv q 12 - 24 h iv.
CrCl < 10: 500 mg iv q 24 - 48 h iv.
Hemodialysis: 1 gm load then 1 g after dialysis.
Peritoneal dialysis: 500 mg q 24 h iv or 250 mg/2L dialysate.
Important side effects
Important drug interactions
Chloramphenicol is antagonistic.
Rants and Screeds
Not as good against E. coli as cefotaxime.
Pearls
Treatment of choice
Use for
Pseudomonas, although it has been supplanted by cefepime.
Arthritis, Brain abscess, bronchiectasis, Cellulitis, Cystic fibrosis, E. coli infections, Neutropenia and fever, gynecologic infections, Intraabdominal infections, Melioidosis, Meningitis, ophthalmic infections, Osteomyelitis, Otitis media, Peritonitis, PID, Pneumonia, Sepsis, UTI.
Don't use for
Class
Third-generation cephalosporin.
Last Update: 08/08/19.