Infectious Disease Compendium

Nafcillin (Unipen®)

Dosing

CrCl Formula

CrCl > 80: 1 - 2 g iv q 4 h.

CrCl 80-50: 1 - 2 g iv q 4 h.

CrCl 50-10: 1 - 2 g iv q 4 h.

CrCl < 10: 1 - 2 g iv q 4 h.

Hemodialysis: 1 - 2 g iv q 4 h.

Peritoneal dialysis:

Obesity dosing

Important side effects

Interstitial nephritis and bone marrow suppression.

Important drug interactions

Cyclosporine, nifedipine, warfarin.

Rants and Screeds

Pearls

It is hard on peripheral veins which is why I use cefazolin for uncomplicated cellulitis. Interchangeable with oxacillin.

Treatment of choice

S. aureus.

Arthritis, Brodie's abscess, Cellulitis, Endocarditis, Impetigo, Meningitis, Osteomyelitis, Pneumonia, surgical prophylaxis.

Use for

All gram-positive cocci except the enterococcus.

Don't use for

Class

Penicillin.

Last update 11/29/19