Dosing
CrCl > 80: 7 mg / kg q 8 h.
CrCl 80-50: 7 mg / kg q 8 h.
CrCl 50-10: ?
CrCl < 10: ?
Hemodialysis:
Peritoneal dialysis:
Important side effects
Arthralgias (especially in liver disease), myalgias, diarrhea, headache, hyperbilirubinemia (common), infusion site inflammation, nausea, vomiting, rash, thrombophlebitis.
Important drug interactions
Alfuzosin, amlodipine, astemizole, atorvastatin, carbamazepine, cerivastatin, cisapride, cyclosporine, delavirdine, diazepam, digoxin, diltiazem, disopyramide, docetaxel, eletriptan, felodipine, fluvastatin, indinavir, isradipine, lacidipine, lidocaine, lovastatin, manidipine, methylprednisolone, midazolam, nevirapine, nicardipine, nifedipine, nilvadipine, nimodipine, nisoldipine, nitrendipine, paclitaxel, pravastatin, quinidine, ritonavir, simvastatin, tacrolimus, terfenadine, verapamil, vinca alkaloids.
Rants and Screeds
Pearls
If the staphylococcus is resistant to erythromycin, it is also resistant to the dalfopristin and the drug goes from bacteriocidal-ish to static. NOT active against Enterococcus faecalis.
Treatment of choice
Use for
VRE and MRSA when vancomycin is not an option. I would say it is at the end of the list for drugs to use against MRSA.
Don't use for
Class
Last update 11/30/19