Dosing
For up-to-date information, go to http://hivinsite.ucsf.edu/tables.
CrCl > 50: Tenofovir disoproxil 300 mg po qd.
Tenofovir alafenamide 25 mg po qd
CrCl 30-49: 300 mg every 48 hr.
CrCl 10-29 mL/min, 300 mg twice weekly.
CrCl 10-29: 300 mg twice weekly.
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Asthenia, bone mineral density loss, diarrhea, flatulence, nausea, vomiting, fat redistribution, hepatitis B exacerbation, lactic acidosis/severe hepatomegaly with steatosis, renal impairment, renal failure, Fanconi syndrome.
Important drug interactions
Atazanavir, didanosine, ritonavir.
Protease inhibitors increase nephrotoxicity more than NNRTI's (PubMed).
Rants and Screeds
Pearls
Treatment of choice
Use for
HIV.
Don't use for
Class
Nucleotide analog reverse transcriptase inhibitor.
Last update 11/30/19