Dosing
CrCl Formula
CrCl > 80: 1-2 gm iv q 12 h.
CrCl 80-50: 1-2 gm iv q 12 h.
CrCl 50-10: 1-2 gm iv q 24 h.
CrCl < 10: 1-2 gm iv q 48 h.
Hemodialysis: 25 on non-hemodialysis days, 50% on hemodialysis days.
Peritoneal dialysis:
Important side effects
Hypoprothrombinemia with an increase in protime.
Important drug interactions
Heparin, warfarin due to hypoprothrombinemia with an increase in protime.
Rants and Screeds
No clinical indication for real infections, its major use is surgical prophylaxis.
Pearls
Treatment of choice
Use for
Arthritis, Cellulitis, cesarean section, Diverticulosis/itis, Endometritis, Gonorrhea, Intraabdominal infections, intrapelvic cellulitis, Osteomyelitis, PID, pelvic peritonitis, Pneumonia, surgical prophylaxis, Pharyngitis, UTI.
Don't use for
It does not cover the 'dot' group of Bacteroides.
Class
Second-generation cephalosporin, technically a cephamycin.
Last Update: 08/06/19.