Dosing
No longer available in the US.
CrCl > 80: 5-6 gm q 4 h iv.
CrCl 80-50: 5-6 gm q 4 h iv.
CrCl 50-10: 2-3 g q 6 h iv.
CrCl < 10: don't give it.
Hemodialysis: 750 mg - 2 g iv after.
Peritoneal dialysis: 2 g q 6 - 12 h iv.
Important side effects
Important drug interactions
Rants and Screeds
Pearls
Treatment of choice
Use for
UTI from Pseudomonas aeruginosa, Escherichia coli, and Proteus.
Don't use for
Almost a drug of historical interest, it has been superseded by ticarcillin, then mezlocillin, and then piperacillin.
Class
Penicillin.
Last Update 06/25/19