Dosing
CrCl > 80: 30 to 50 mg/kg qod for 10 x 15 doses.
CrCl 80-50: 400
CrCl 50-10:
CrCl <10: na
Hemodialysis : no data.
Peritoneal dialysis: no data.
Important side effects
Common: gastrointestinal (nausea, vomiting, diarrhea, abdominal pain) and skin rashes. Photosensitivity reactions, angioedema, headache, dizziness, and hypotension with respiratory distress less often.
Important drug interactions
Rants and Screeds
Pearls
Bithionol is investigational in the US. The drug can be obtained from the Centers for Disease Control (CDC) Drug Service, CDC.
Use for
Treatment of choice
Don't use for
Class
Chlorinated phenol. That just sounds bad. It inhibits soluble adenylyl cyclase.