Infectious Disease Compendium

Niridazole

Dosing

CrCl Formula

CrCl > 80: 25 mg/kg given for 5-7 days or 30 mg/kg for 4 days po depending on pathogen.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

CNS toxic.

Important drug interactions

Rants and Screeds

Pearls

Treatment of choice

Use for

Schistosomiasis. Effective against S. haematobium and S. mansoni, but less so against S. japonicum and S. intercalatum infections.

Dracunculiasis and tungiasis.

Don't use for

Class

Inhibits the phosphofructokinase enzyme

Last update 11/29/19