(PubMed)
Dosing
CrCl > 80:
No net alteration in metabolism: Tipranavir plus ritonavir, nevirapine, all NRTIs, and enfuvirtide 300 mg BID.
CYP3A inhibitors (with or without a CYP3A inducer): Ritonavir, all boosted protease inhibitors (except tipranavir plus ritonavir), delavirdine, ketoconazole, itraconazole, clarithromycin, nefazadone, and telithromycin 150 mg BID.
CYP3A inducers alone Efavirenz, etravirine, rifampin, carbamazepine, phenobarbital, and phenytoin 600 mg BID.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Hepatitis.Important drug interactions
Rants and Screeds
Pearls
Treatment of choice
Use for
Don't use for
Class
It inhibits the interaction between the chemokine receptor CCR5 and HIV-1 gp120.
Last update 11/29/19