Dosing
CrCl > 80: 200 to 300 mg per kg per day in 2 - 4 divided doses.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects:
Abdominal pain, diarrhea, hepatotoxicity (common), hypersensitivity reactions, nausea, vomiting, thrombocytopenia.
Important drug interactions
Cyanocobalamin, digoxin, ethionamide, isoniazid.
Rants and Screeds
Pearls
Treatment of choice
Use for:
Second-line for really resistant MTb.
Don't use for
Class
A competitive antagonist of folic acid synthesis.
Last update 11/30/19