Dosing
CrCl > 80: 1 gm IM or IV q 24 h.
CrCl 80-50: 1 gm IM or IV q 24 h.
CrCl 50-10: 7.5 mg/kg q 24 - 48 h IM or IV.
CrCl < 10: 7.5 mg/kg IM or IV 2x / wk.
Hemodialysis:
Peritoneal dialysis:
Important side effects
Abnormal LFT's, eosinophilia, hypokalemia, injection site pain, nephrotoxicity, ototoxicity, urticaria, maculopapular rash.
Important drug interactions
Increased ototoxic or nephrotoxic potential with other drugs with this effect. Neuromuscular blockade.
Rants and Screeds
Pearls
Treatment of choice
Use for
Mycobacterium tuberculosis (second line drug).
Don't use for
Class
Aminoglycoside.
Last Update: 06/22/19.