Infectious Disease Compendium

Cefoperazone (Cefobid®)

Dosing

CrCl Formula

CrCl > 80: 1 - 2 g iv q 6 - 12 h.

CrCl 80-50: 1 - 2 g iv q 6 - 12 h.

CrCl 50-10: 1 - 2 g iv q 6 - 12 h.

CrCl < 10: 1 - 2 g iv q 6 - 12 h.

Hemodialysis: dose after dialysis

Peritoneal dialysis:

Important side effects

Hypoprothrombinemia with an increase in the protime.

Important drug interactions

Heparin, warfarin due to hypoprothrombinemia with an increase in the protime.

Rants and Screeds

Pearls

No longer available in the US.

Treatment of choice

Use for

Anything you would use a third-generation cephalosporin for Cellulitis, Cholangitis, Cholecystitis, Gonorrhea, Intraabdominal infections, PID, Peritonitis, Pneumonia, Meningitis, ocular infections, Osteomyelitis, Otitis media, peritoneal dialysis, Peritonitis, Proteus mirabilis infections, Pneumonia, Sepsis, UTI.

Don't use for

Class

Third-generation cephalosporin.

Last Update: 08/05/19.