Dosing
For up-to-date information, go to http://hivinsite.ucsf.edu/tables.
CrCl > 80: 800 mg po tid.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Pure indinavir renal stones; the worlds most expensive stones. abdominal pain, nausea, vomiting, acute hemolytic anemia, asymptomatic hyperbilirubinemia, back pain, fat redistribution, hepatitis (including liver failure and death (rare)), hyperglycemia (including cases of new onset diabetes mellitus), immune reconstitution syndrome.
Important drug interactions
Alfuzosin, amiodarone, amprenavir, ascorbic acid, astemizole, amprenavir, atorvastatin, calcium channel blockers, carbamazepine, cerivastatin, cisapride, cyclosporine, dalfopristin, delavirdine, dexamethasone, didanosine, efavirenz, eletriptan, ergot derivatives, erlotinib, fentanyl, fosamprenavir, fosphenytoin, ivermectin, ketoconazole, levodopa, lovastatin, midazolam, nevirapine, phenobarbital, phenytoin, pimozide, quinupristin, rifabutin, rifampin, rifapentine, ritonavir, saquinavir, sildenafil, simvastatin, st john's wort, tadalafil, terfenadine, trazodone hydrochloride, triazolam, vardenafil.
Rants and Screeds
Pearls
Treatment of choice
Use for
HIV.
Don't use for
Class
Protease inhibitor.
Last update 11/27/19