Dosing
CrCl Formula
CrCl > 80: 1 g po bid. Take with vitamin C to keep urine pH low.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Important drug interactions
Antacids, sulfamethizole.
Rants and Screeds
Pearls
Have to keep the pH < 6 to work. Urea-splitting organisms (Proteus species) will not respond as they prevent urine acidification.
Treatment of choice
Use for
UTI, both treatment and prophylaxis.
Don't use for
Class
Turns into formaldehyde in acidic urine.
Last update 11/29/19