Dosing
CrCl > 80: 300 mg po qd.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Peripheral neuropathy, take with vitamin B6 to prevent. Age-related chemical hepatitis, espcially when age > 35.
Agranulocytosis (rare), anemia (rare), seizures, skin reactions, systemic lupus erythematosus (rare), urticaria.
Important drug interactions
Acetaminophen, alprazolam, para-aminosalicyclic acid, carbamazepine, cycloserine, diazepam, disulfiram, enflurane, ethionamide, fosphenytoin, itraconazole, ketoconazole, levodopa, meperidine, phenytoin, rifampin, sevoflurane, valproic acid, warfarin.
Rants and Screeds
Pearls
Treatment of choice
Use for
Mycobacterium infections and prophylaxis.
Don't use for
Class
Last update 11/27/19