Infectious Disease Compendium

Aztreonam (Azactam)

Dosing

CrCl Formula

CrCl > 80: 1-2 gm q 6 h.

CrCl 80-50: q 8-12 h.

CrCl 50-10: q 12 - 18 h.

CrCl < 10: q 24 h.

Hemodialysis 1/8 initial dose.

Peritoneal dialysis:

Obesity dosing

Important side effects

No unusual.

Important drug interactions

No unusual.

Rants and Screeds

Pearls

Safe with anaphylactic reactions to other beta-lactams.

Treatment of choice

Use for

Gram-negative aerobic organisms like E. coli and Pseudomonas.

Nebulized aztreonam is used for the treatment of respiratory symptoms in cystic fibrosis.

Don't use for

All gram-positives. And for ESBL, which hydrolyzes aztreonam.

And anaerobes.

Class

Monobactam

Last Update: 04/17/19.