Dosing
CrCl > 80: 150 mg BID for IV and 600 mg BID po.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Liver enzyme elevation and prolongs QT interval.
Important drug interactions
Rants and Screeds
Pearls
Treatment of choice
Use for
CAP (FDA approved) (PubMed) and cellulitis.
Gram-positives: Streptococcus pneumoniae, Staphylococcus aureus [including MRSA], Enterococcus faecium [including VRE], coagulase negative staphylococci, beta-hemolytic streptococci, viridans group streptococci. Gram-negatives: Haemophilus influenzae, Neisseria gonorrhoeae, Moraxella catarrhalis. Atypicals: Mycoplasma pneumoniae, Legionella pneumophila, and Chlamydophila pneumoniae, Mycoplasma genitalium.
Don't use for
Class
Pleuromutilin antibiotic: inhibits bacterial protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, which prevents the binding of transfer RNA for peptide transfer.
Last Update: 10/16/19.