Infectious Disease Compendium

Cefamandol (Mandol®)

Dosing

CrCl Formula

CrCl > 80: 500 mg - 2 g q 4 - 8 h iv.

CrCl 80-50: 500 mg - 2 g q 6 h iv.

CrCl 50-10: 500 mg - 2 g q 8 h iv.

CrCl < 10: 500 mg - 1 g q 12 h iv.

Hemodialysis:

Peritoneal dialysis:

Important side effects

Important drug interactions

Heparin coagulation abnormalities due to a direct effect on prothrombin time or vitamin K production. Warfarin hypoprothrombinemia and/or prolonged bleeding time.

Rants and Screeds

Pearls

When I was a resident, 1983-1986, we had no third-generation cephalosporins, and this was the goto antibiotic for CAP. Mandol on call we would say. Does anyone use it anymore? It is no longer available in the US.

Treatment of choice

Use for

Arthritis, Osteomyelitis, Peritonitis, Pneumonia, surgical prophylaxis.

Don't use for

Class

Second-generation cephalosporin.

Last Update: 07/04/19