Dosing
CrCl > 80: 15 - 30 mg/kg po q 24 h.
CrCl 80-50: 15 - 30 mg/kg po q 24 h.
CrCl 50-10: 15 - 30 mg/kg po q 24 h.
CrCl < 10: 12-20 mg/kg po q 24 h.
Hemodialysis: 12 to 20 mg/kg/day OR 40 mg/kg three times weekly OR 60 mg/kg twice weekly.
Peritoneal dialysis:
Important side effects
Arthralgia (common), anemia, hepatotoxicity, hyperuricemia, nausea, vomiting.
Important drug interactions
Cyclosporine, ethionamide, probenecid, rifampin, zidovudine.
Rants and Screeds
Pearls
Treatment of choice
Use for
Don't use for
Class
Last update 11/30/19