Dosing
CrCl > 80: 4 mg/kg iv q 24 h. Inhaled for PJP prophylaxis is 300 mg q 3 - 4 weeks.
CrCl 80-50: 4 mg/kg iv q 24 h.
CrCl 50-10: 4 mg/kg iv q 24 h.
CrCl < 10: 4 mg/kg iv q 24 h.
Hemodialysis:
Peritoneal dialysis:
Important side effects
Renal failure. Poisons islet cells, so get hypoglycemia followed by hyperglycemia. acute pancreatitis, anorexia, nausea, bronchospasm, cough, dyspnea (inhalation only), cardiac arrhythmias, elevated liver function tests, extravasation; ulceration, tissue necrosis, sloughing, hypotension, leukopenia, thrombocytopenia, rash.
Important drug interactions
Antipsychotics, arsenic trioxide, astemizole, bepridil, chloral hydrate, chloroquine, cidofovir, cisapride, clarithromycin, class i antiarrhythmic agents, class ia antiarrhythmic agents, class iii antiarrhythmic agents, cotrimoxazole, dolasetron, droperidol, enflurane, erythromycin, erythromycin/sulfisoxazole, fluconazole, fluoxetine, foscarnet, gemifloxacin, grepafloxacin, halofantrine, halothane, isoflurane, isradipine, levomethadyl, lidoflazine, mefloquine, mesoridazine, octreotide, phenothiazines, pimozide, probucol, sparfloxacin, spiramycin, sulfamethoxazole, telithromycin, terfenadine, thioridazine, tricyclic antidepressants, trimethoprim, vasopressin, venlafaxine, zalcitabine, ziprasidone, zolmitriptan.
Rants and Screeds
Pearls
Treatment of choice
Use for
PJP treatment and prophylaxis.
Acanthamoeba meningoencephalitis, Babesia, Leishmania, Trypanosoma.
Don't use for
Class
Last update 11/30/19