Dosing
CrCl > 80: 2.5 g every 8 hours
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Important drug interactions
Rants and Screeds
$332 a dose as of 10/1/16. Ouch.
Pearls
Treatment of choice
Use for
Adding avibactam to ceftazidime increases activity against carbapenem-resistant pathogens with OXA-48, KPC, AmpC (including derepressed hyperproducing Enterobacter) and has similar spectrum/coverage against ESBLs as carbapenems.
Don't use for
Metallo-beta-lactamases are not inhibited by avibactam. Useful against the KPC.
Treating carbapenem-resistant E. coli and K. pneumoniae has a high failure rate (PubMed).
Class
Cephlosporin/ non-beta-lactam beta-lactamase combination.
Last Update: 08/21/19.