Infectious Disease Compendium

Plazomicin

Dosing

CrCl Formula

CrCl > 60: 15 mg per kilogram daily.

CrCl ≥30 to 60 mL/min: 10 mg/kg IV q 24 hr .

CrCl ≥15 to 30 mL/min: 10 mg/kg IV q 48 hr.

Hemodialysis:

Peritoneal dialysis:

Important side effects

Oto and nephrotoxicity.

Important drug interactions

Rants and Screeds

Pearls

Treatment of choice

Use for

CRE E. coli and K. pneumoniae UTI (PubMed) and bloodstream infections (PubMed).

Don't use for

Class

Aminoglycoside. "Plazomicin is an aminoglycoside that is engineered to evade modification by aminoglycoside- modifying enzymes, and it maintains activity in the presence of most mechanisms that lead to resistance in Enterobacteriaceae, including mutations in sites targeted by fluoroquinolones and the production of aminoglycoside-modifying enzymes, extended-spectrum β-lactamases, and carbapenemases (PubMed)."

Last update 11/30/19