Dosing
CrCl > 80: 400 mg a day for two weeks and then 200 mg taken three times a week (with at least 48 hours between doses) for the next 22 weeks
CrCl 80-50: 400
CrCl 50-10:
CrCl <10: na
Hemodialysis : no data.
Peritoneal dialysis: no data.
Important side effects
Common: gastrointestinal (nausea, vomiting, diarrhea, abdominal pain), arthralgias headaches, and chest pain, QT prolongation, liver dysfunction.
Important drug interactions
Rants and Screeds
Pearls
When resistance occurs, which it has, it has cross resistance with clofazamine.
Use for
MDR Mycobacterium tuberculosis.Treatment of choice
Don't use for
Class
Diarylquinoline. It blocks the ability of M. tuberculosis to make adenosine 5'-triphosphate (ATP).
Last Update: 05/19/18.