Infectious Disease Compendium

Delafloxacin

Dosing

CrCl Formula

CrCl > 29: 300mg iv q 12 h.

450 mg po q 12 h.

CrCl 80-50:

CrCl 15–29 mL/min 200 mg IV q 12h

Hemodialysis:

Peritoneal dialysis:

Important side effects

Usual quinolone issue.

Important drug interactions

As with all quinolones, oral divalent cations will bind the drug and prevent absorption.

Rants and Screeds

C. difficile has good MIC, perhaps why there were no cases in the trials.

Treatment of choice

Use for

Approved for Cellulitis and Pneumonia. Good for MRSA (PubMed) and Streptococci.

Not bad for most anaerobes except Prevotella.

Don't use for

Pseudomonas.

Class

Quinolone.

Curious Cases

Relevant links to my Medscape blog

Back and Annoyed