Dosing
CrCl > 80: 250-500 mg q 8 h or 875 mg po q 12 h.
CrCl 80-50: 250-500 mg q 8 h. CrCl 50-10: q 12 h.
CrCl < 10: q 12-24 h.
Hemodialysis: 250 mg after dialysis.
Peritoneal dialysis:
Important side effects
Diarrhea.
Rants and Screeds
No streptococcus makes a beta-lactamase, so it is way moronic to give this agent when you are worried about a streptococcus.
Pearls
Treatment of choice
In my opinion, nothing. A drug without a use.
Use for
Animal bite prophylaxis. The only use for this drug in my never humble opinion. Unless, of course, you like to give your patients diarrhea.
Don't use for
Anything else. Ever. Wouldn't be prudent. Others use it for Animal bites, Carbuncles, Cellulitis, Chancroid, Diverticulosis/itis, Gonorrhea, lymphadenitis, Mastitis, mycetoma, Nocardia, Otitis media, periodontitis, Pharyngitis, Pneumonia, tonsillitis, UTI.
Class
Penicillin plus a beta-lactamase inhibitor.
Curious Cases
Relevant links to my Medscape blog
Last Update: 04/08/19.