Dosing
CrCl > 80:
Hepatitis B:
CrCl 50 or greater: 10 mg every 24 hours.
CrCl 20 to 49: 10 mg every 48 hours.
CrCl 10 to 19: 10 mg every 72 hours.
CrCl less than 10: no dosing recommendation.
CrCl hemodialysis: 10 mg every 7 days following dialysis.
Important side effects
Nephrotoxicity, decreases in phosphorus, hepatitis.
Lactic acidosis and severe hepatomegaly with steatosis with adefovir alone or with other antiretrovirals.
Use for
Use after a failure of lamivudine in e antigen positive patients.
Class
Acyclic nucleoside analog, it is a reverse transcriptase inhibitor.
Last Update: 03/27/19.