Dosing
CrCl > 50: 500 mg iv q 8.
CrCl ≥30 to ≤50: 250 mg iv q 8 hours.
CrCl > 10 to <30: 250 mg iv q 12 hours
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Important drug interactions
Rants and Screeds
Pearls
There may be better outcomes if given as a 4 hour infusion rather than a one-hour infusion (PubMed).
Treatment of choice
Use for
When compared head to head, it was inferior (more deaths) to imipenem and the trial was stopped early.
FDA approved for complicated intra-abdominal infection and complicated urinary tract infections.
Don't use for
Staphylococcus aureus (MRSA), Enterococcus faecium, and Stenotrophomonas maltophilia.
Class
Carbapenem.
Last update 11/16/19